Compounded Semaglutide GLP-1 Treatment Plan
LAST UPDATED: Oct 17, 2023
We know you’re excited to start treatment. But before your first shot, take the time to read your entire treatment plan to understand the potential risks and benefits of compounded semaglutide. Please do not hesitate to contact our medical support team in your Ro account chat if you have any questions.
HERE'S WHAT WE'LL COVER
How it works:
Like other GLP-1s, compounded semaglutide mimics a naturally occurring hormone in your body that slows down how fast your stomach empties after you eat and acts on your brain to make you less hungry. It’s believed to help you feel fuller quicker and satiated longer and regulate how much you eat.
When to take it:
You'll inject compounded semaglutide once a week. You can take it any day of the week, at any time, either with or without food. Once you pick a day, stick with it each week to make taking your medication a habit.
How to take it:
Compounded semaglutide comes in small glass vials with syringes that you must carefully prepare to self-administer the injectable medication. Like Wegovy and Ozempic, it's injected weekly in your abdomen, thigh, or upper arm.
Watch our injection video, or keep reading for step-by-step instructions. If at any time you feel uncertain about how to use your medication, please send a message to our medical support team.
Potential side effects:
Like other GLP-1s, most common side effects often improve within the first few weeks of treatment. Common side effects are often gastrointestinal complaints like nausea, diarrhea, and vomiting (see the full list below). More severe side effects are rare but possible, so please keep reading to learn about them all.
More on compounding:
Drug compounding is the process of combining, mixing, or altering ingredients to create a medication tailored to an individual patient's needs. Compounding is conducted by pharmacies or other licensed entities, such as physicians or outsourcing facilities. Ro's compounded semaglutide only uses semaglutide base, the same active ingredient used in Wegovy® and Ozempic®.
Watch: How to inject compounded semaglutide
Read: Step-by-step injection instructions
Be sure to read the instructions that come with the medication before taking your first dose.
Each combination of syringe + needle is meant to be used only once. Do not reuse a syringe + needle.
When your medication arrives:
The medication must be stored in the prescription bottle it comes in and placed in your refrigerator as soon as you receive it. The packaging is designed to keep your medication within safe temperature ranges for up to 2 days. If you haven’t refrigerated your medication within 2 days of receiving it, contact us at [email protected].
How to store your medication
Refrigerate your medication as soon as it arrives. Store the vial of medication in the prescription bottle it came in. Keep it in your refrigerator at 36º–46º F (2º–8º C). Discard any unused medication 28 days after first using the vial or when the expiration date has passed, whichever comes first.
What to do if you have a previous prescription
If you have a previous prescription for a brand-name semaglutide or another GLP-1 in addition to your compounded semaglutide, do not take both medications simultaneously. Instead, discard your previously prescribed medication. Taking two or more of these medications together increases potentially severe side effects.
When to take your dose
Administer one dose each week, on the same day each week, at any time of day, with or without food.
What to have ready
one (1) vial of medication
one (1) sterile syringe with needle
two (2) alcohol wipes
one (1) vial seal sticker
hard plastic resealable container to dispose of used needle and syringe
Before you start
1. Wash your hands with soap and water.
2. Double-check the information on the vial, including the dose amount and expiration date. The medication should be clear and colorless.
Filling the syringe
3. Gently shake the vial. If this is a new vial, remove the plastic cap. If not, remove the seal sticker you previously placed on the top. Now, clean the top of the vial with an alcohol wipe.
4. On the syringe, remove the caps from the plunger and the needle. It’s important to keep the needle sterile, so do not touch it.
5. While holding the syringe with the needle pointed up, pull the plunger down to the correct dose. Use the chart below:
Compounded Semaglutide Dosage
How much to draw
0.25 mg (0.1 mL)
0.5 mg (0.2 mL)
1 mg (0.4 mL)
2 mg (0.8 mL)
For example, if your dose is 0.25 mg, pull the plunger of the syringe down to the 10 units mark.
6. Insert the needle into the rubber part of the vial top and press down on the plunger completely to inject all of the air from the syringe into the vial. Injecting the air into the medication vial makes the next step easier!
7. While the needle is still in the vial, turn the vial upside down. Make sure the needle tip is surrounded by liquid. Pull back the plunger past your dose amount. For example, if your dose is 10 units of medication, pull the plunger back beyond the 10 units mark.
8. Remove any air bubbles by tapping the syringe with your finger.
9. Push the plunger to the prescribed dose level on the syringe. For example, if your prescribed dose is 10 units, push the plunger to the 10 units mark.
10. Turn the vial upright and then remove the needle.
11. Do not put the needle cap back on the needle. You can put the syringe down by resting it on the needle cap so the tip of the needle doesn’t touch anything.
12. Apply a new vial seal sticker to the cap of the vial after each use. Press firmly to ensure adherence to the cap to prevent contamination.
Administering the injection:
13. Select your injection site. Your abdomen (at least two inches away from your belly button), thigh (front or outer thigh), or upper arm are all good injection sites, but choose a spot that is at least one finger’s width away from the last injection spot.
Change where you give the injection each time. You can inject in the same area of your body each time—just make sure it’s not in the exact same spot every time. Moving injection spots is important to minimize the formation of permanent, fatty nodules that can arise and decrease the efficacy of your treatment. Ensure each injection location is at least one finger’s width away from the previous one.
14. Clean the area you want to inject with an alcohol wipe and allow the skin to dry.
15. Hold the syringe with the needle facing toward the ceiling. Push the plunger slightly until a drop of liquid forms at the end of the needle.
16. Pinch and hold the skin that you will inject. Holding the syringe pointing directly at the pinched skin, quickly push the needle through the skin into the fat tissue, making sure to insert the entire length of the needle. Then, slowly push the plunger to inject all of the medication.
17. Pull the needle out and clean the skin with an alcohol wipe or tissue. It’s normal to see a drop of blood at the injection spot. Press gently on the site for a few seconds for the bleeding to stop.
Safely discard the syringe:
18. Discard the syringe in a sharps container or a heavy plastic container with a tight-fitting lid, like an empty detergent bottle. Do not throw away the syringe in your household trash.