Important safety information
What you should know before taking Zepbound.
The fastest-working weight loss medication
Zepbound® prescription online for weight loss
Together with LillyDirect, Ro now offers authentic Zepbound (tirzepatide) in a vial. Shipped directly to you, it’s the most convenient way to start your weight loss journey.
A new way to access FDA-approved GLP-1s. See safety info below
The fastest way to lose weight, at half the list price*
Targets two hormone receptors to curb both hunger and nausea
At Ro, you’ve got options – access Zepbound in a single-dose vial or prefilled pen.
What is Zepbound?
Zepbound uses the same active ingredient (tirzepatide) as Mounjaro®. It’s a dual-action GLP-1/GIP-receptor agonist that is approved by the FDA for people with obesity, or overweight plus a weight-related condition, along with diet and exercise changes.
How is Zepbound different from Ozempic® or Wegovy®?
Zepbound and Wegovy are approved by the FDA for weight loss, while Ozempic is approved for the treatment of type 2 diabetes, but can be prescribed off-label for weight loss, if appropriate.
The main difference between these medications is the active ingredient. Ozempic and Wegovy use semaglutide, while Zepbound uses tirzepatide. Tirzepatide is a dual-action GLP-1 and GIP, meaning it works by activating two receptors to curb nausea and regulate your metabolism, helping you feel full faster and longer. In comparison, semaglutide only activates the GLP-1 receptor.
What’s the difference between Zepbound pens and vials?
Zepbound pens and vials are the exact same FDA-approved medication, but are available in different dosage forms and strengths. This means that when the medication is used in the same dose – whether taken via a vial or pen – it has the same efficacy and side effects.
The primary difference is that the vials are only available in 2.5 mg and 5 mg doses, while the pens include those doses as well as 7.5 mg, 10 mg, 12.5 mg, and 15 mg. In clinical trials, patients on the 5 mg dose (maximum dose in single-dose vials) lost an average of 15% of their body weight in a year, while those on the 15 mg dose (maximum dose in single-dose pens) lost an average of 20% in a year.
One other difference is that pens are prefilled, while the vials are administered with a syringe. We provide clear, straightforward instructions and a video walkthrough to help you do this, plus Ro-affiliated providers and nurses are available to help if you have any questions.
Lastly, Zepbound vials can be shipped conveniently and directly to you from the LillyDirect partner pharmacy. The vials are only available when paying cash, and are not eligible for insurance coverage. You can opt to pay for Zepbound pens out-of-pocket, or use insurance (if coverage is available). The pens can only be fulfilled through your preferred pharmacy.
*Price compared to the list price of Zepbound autoinjector pen, without applying insurance or savings cards. Zepbound vials are a cash-pay offering only. Full weight loss results are seen at about 1 year, when combined with diet and exercise.
Safety info: GLP-1 medications are used to treat obesity or overweight (with weight-related problems), along with diet and exercise. They may have serious side effects, including possible thyroid tumors. Do not use if you or your family have a history of a type of thyroid cancer called MTC or MEN 2. See more serious warnings & safety info.
Select your current weight
252lbs
Weight you could lose (lbs):
50lbs
*In a 72-week clinical trial studying Zepbound in non-diabetic patients with obesity or with overweight, plus a weight-related condition, the average weight loss was 15% (5 mg vial) and 20% (15 mg pen), when paired with diet and exercise changes (compared to 3.1% with diet and exercise alone).
How Ro helps you lose weight
Whether you want to check your insurance coverage or prefer to pay cash, we got you. Once you’re a member, we take care of any paperwork and insurance back-and-forth so you don’t have to lift a finger.
Getting started
Answer health questions and complete your online visit
Share your health history and weight loss goals with us online to get started. A Ro-affiliated provider will review your answers and get back to you within a few days. Depending on your health review, a provider may order a metabolic lab test before moving forward with treatment.
Provider writes an Rx (if appropriate)
After reviewing your results, your provider will determine if you’re eligible for medication. If you are, they’ll tailor a program with prescription treatment best suited to your unique biology.
Check your insurance coverage
If you’d like to use insurance, a dedicated team will connect with your insurance company to determine your coverage. If you’d prefer to pay cash or if coverage is denied, we’ll help you understand your options across our full GLP-1 suite. Zepbound vials cannot be purchased with insurance, and are cash pay only.
Ongoing monthly care
Access medication
If you’re prescribed Zepbound vials or compounded semaglutide, your medication will typically be shipped to you in 1-4 days. If you're prescribed a GLP-1 pen, you’ll get your prescription from your preferred pharmacy. Medication costs are not included in Body membership pricing.
Ongoing care and support
You’ll have everything you need, including on-demand provider messaging, personalized medication adjustments, and expert guidance on what to expect on your journey – all as part of your membership.
Gray lost 50 lbs in 21 months
“With Ro, you actually get to talk to people. It just makes you feel supported and like you can do it."
Gray Ro member and paid partner using Zepbound pen
Roman lost 46 lbs in 8 months
“I can't even tell you the mindset and clarity this has given me. Yes, the weight came off quick, but there is so much more to it that I didn't even expect.”
Roman Ro member and paid partner using Zepbound
Meet our expert
From diagnosis to delivery, our healthcare providers are with patients every step of the way.
Hear from Ro members
Ro members taking branded GLP-1 medications were paid for their testimonials.
Sonia
Ro member
“I’ve had some pretty amazing success. I’m down 15 pounds and I couldn’t be happier."
James
Ro member
“It's really helping handle my cravings better, which is what I really like about this program."
Chaleeta
Ro member
“It was like a switch once I started the medication, I just wasn’t so obsessed with food.”
Zepbound FAQs
Can I get Zepbound through Ro?
Yes! If you're interested in starting treatment with Zepbound—whether single-dose pens or vials–the first step is completing an online visit so that a medical provider can determine if treatment is right for you. If you’re prescribed Zepbound single-dose vials, they will be shipped directly to your door via the LillyDirect partner pharmacy.
What’s the difference between Zepbound pens and vials?
Zepbound pens and vials are the exact same FDA-approved medication, but are available in different dosage forms and strengths. This means that when the medication is used in the same dose – whether taken via a vial or pen – it has the same efficacy and side effects.
The primary difference is that the vials are only available in 2.5 mg and 5 mg doses, while the pens include those doses as well as 7.5 mg, 10 mg, 12.5 mg, and 15 mg. In clinical trials, patients on the 5 mg dose (maximum dose in single-dose vials) lost an average of 15% of their body weight in a year, while those on the 15 mg dose (maximum dose in single-dose pens) lost an average of 20% in a year.
One other difference is that pens are prefilled, while the vials are administered with a syringe. We provide clear, straightforward instructions and a video walkthrough to help you do this, plus Ro-affiliated providers and nurses are available to help if you have any questions.
Lastly, Zepbound vials can be shipped conveniently and directly to you from the LillyDirect partner pharmacy. The vials are only available when paying cash, and are not eligible for insurance coverage. You can opt to pay for Zepbound pens out-of-pocket, or use insurance (if coverage is available). The pens can only be fulfilled through your preferred pharmacy.
What are the side effects of Zepbound?
Like other GLP-1 medications, Zepbound comes with the risk of potential side effects. Most people experience these side effects when their dose is increased, and they tend to improve once a steady dose is reached. Some of the most common side effects include:
Nausea
Diarrhea
Vomiting
Constipation
Stomach pains
Upset stomach
Indigestion
Injection-site reactions
Fatigue
Belching and gas
Hair loss
Heartburn
Additionally, if you take oral birth control pills, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.
More severe side effects are rarer but possible. Serious side effects include:
Thyroid cancer: Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Severe stomach problems
Pancreatitis
Gallbladder disease
Rapid heartbeat
Severe allergy (hypersensitivity)
Low blood sugar
Changes in vision in patients with type 2 diabetes
Kidney disease
Suicidal thoughts or behaviors
Pulmonary aspiration during general anesthesia or deep sedation: . In rare instances, some patients undergoing anesthesia during surgical procedures have had stomach contents enter their lungs, which can cause pneumonia and other problems.
You can report quality complaints and side effects to The Lilly Answers Center (TLAC) at +1(800) 545-5979 to notify Lilly, the manufacturer of your medication. They use side effect information to monitor and sometimes report on drug safety.
These are not all of the possible side effects of Zepbound. For more complete information about Zepbound, including Boxed warning, see full Important Safety Information.
How do you store Zepbound?
Both Zepbound pens and vials should be stored in the refrigerator at 36-46º F, but they may be kept between 46-86º F for up to 21 days, if needed. Store unopened pens and vials in their original cartons to protect them from light.
If you store Zepbound pens at room temperature, do not return them to the refrigerator. Do not freeze the pens. The pen contains glass parts, so if you drop the pen on a hard surface, do not use the pen for your injection.
If you store Zepbound vials at room temperature, throw away any unused portion after 21 days. Do not freeze the medication, and do not use it if it has been frozen. Be sure to throw away any opened vial after using it, even if there is medication left in the vial.
How much does Zepbound cost?
This depends whether you’re prescribed Zepbound single-dose pens or vials.
For Zepbound pens, insurance coverage and copays will vary depending on your plan. Our insurance concierge will work with your provider to determine your coverage for GLP-1 medication and, if necessary, submit a prior authorization request for you. If you’re paying cash, Zepbound pens cost about $1,050/mo. If you have commercial insurance, you may be eligible for a discount through the manufacturer. Learn more about the Zepbound savings card here.
The savings card program doesn’t apply to Zepbound single-dose vials, which are available as a cash pay-only offering:
2.5 mg dose – $399/mo
5 mg dose – $549/mo
These medication costs are separate from your Body membership ($45 first month, $145/mo thereafter), which includes our insurance concierge, provider visits, ongoing coaching, and anytime messaging. Learn more about pricing here.
From the experts at ro