In stock

Tretinoin, tailored to you.

Take 25% off your first order $58Sale price $43*

In stock ready to ship

Connect with a healthcare provider to find out if a customized, prescription skincare treatment with tretinoin is right...

Free, unlimited follow-ups

Customized blends

Address your skin concerns

Free 2-day shipping


Tap into custom care

Dermatologist-designed, free, 10-minute online visit

Custom Rx Treatment tailored to your goals, if prescribed

Confidence in your skin and your skincare

Dermatologist-selected, science-backed ingredients

Depending on your prescription, your Custom Rx Treatment may contain:

  • Tretinoin

    Acne, uneven skin tone and texture, fine lines and wrinkles, dark spots, clogged pores, dullness
  • Niacinamide

    Acne, inflammation, blemishes, uneven skin tone
  • Azelaic acid

    Acne, inflammation, blemishes, uneven skin tone
  • Tranexamic acid

    Dark spots, discoloration, uneven skin tone
  • Vitamin E

    Dryness, uneven skin texture
  • Hyaluronic acid

    Dryness, dullness
Bailey regained her confidence with Custom Rx Treatment.

After years of relentless acne breakouts, dark spots, dermatologist appointments, and prescriptions that didn’t work, Bailey found clearer skin with Ro Derm.

"I feel so much better and I've had a major confidence boost."

– Bailey, verified Ro Derm member


Our version of show (or glow) and tell: See photos of real Ro Derm patients throuhgout their skincare journey (after at least 6 months of treatment on Custom Rx Treatment).

Take 25% off your first order, if prescribed
  • Custom Rx Treatment: normally $58; $43/first 2-month order

Complete your routine with dermatologist-backed products
  • Enriching Cream: normally +$16; +$12/first order

  • Hydrating Cleanser: normally +$12; +$9/first order

  • Protecting SPF Lotion: normally +$12; +$9/first order

After your 25% off first order trial, you will be billed - $58 for Custom Rx Treatment, +$16 for the Enriching Cream, +$12 for Hydrating Cleanser, +$12 for Protecting SPF Lotion - until you cancel.

Free and unlimited check-ins

You’re not on your skincare journey alone. Your provider will follow up on your progress, help you manage any side effects, and, as your skin evolves, adjust your treatment as needed to optimize results.


Still have questions?

Visit the FAQs page

Your goals are our goals, and we love hearing about how things are going*

  • "I was amazed at how quickly I received my order and how helpful my doctor has been "

    Ro Derm member

  • "I know tretinoin and niacinamide can take several months to notice results, but in the 3 months I’ve been using it I’ve noticed results. My pores are smaller and look less clogged. My skin texture is smoother."

    Ro Derm member

  • "I'm 49 and people say my skin looks 28."

    Ro Derm member

  • "Incredible. I have my skin back, along with my confidence!"

    Ro Derm member

  • "My skin has drastically changed. It's more clear, no new breakouts, visibly less skin feels fresh!"

    Ro Derm member

  • "Trustworthy, convenient, personalized care!"

    Ro Derm member

*These testimonials were submitted by verified members for Rory Nightly Defense, which is the previous name of Ro Derm Custom Rx Treatment—the formulas did not change when the product was renamed. The members received their treatment at no cost for offering their photos and/or testimonials.

Discover more

Your routine, your way

Set your skin up for success with dermatologist-backed picks.

  • Custom Rx Treatment

    High-performing. Goal-targeting. Award-winning.

  • Enriching Cream

    Moisture-locking. Barrier-supporting. Skin-nourishing.

  • Hydrating Cleanser

    Invigorating. Non-lathering. Deeply cleansing.

  • Protecting SPF Lotion

    UVA- and UVB-protecting. Lightly hydrating ingredients.