Custom Rx Treatment

from $58Sale price $43/2 months 25% off first order

Meet prescription skincare powered by tretinoin. Your treatment will be customized for your skin type and skin goals,...

US-licensed healthcare providers

Dermatologist-designed program

Prescription actives and skin-nourishing ingredients


Free shipping

Billed and shipped every 2 months

Dermatologist-selected, science-backed ingredients

Depending on your prescription, your Custom Rx Treatment may contain:

  • Tretinoin

    Dark spots, uneven skin tone and texture, fine lines and wrinkles, acne, clogged pores, dullness

  • Niacinamide

    Acne, inflammation, blemishes, uneven skin tone

  • Azelaic acid

    Acne, inflammation, blemishes, uneven skin tone

  • Tranexamic acid

    Dark spots, discoloration, uneven skin tone

  • Vitamin E

    Dryness, uneven skin texture

  • Hyaluronic acid

    Dryness, dullness

  • Ceramides

    Dryness, uneven skin tone

Your goals are our goals*

Show (or glow) and tell is always welcome here: We love hearing how things are going.

*These testimonials were submitted by verified members for Rory Nightly Defense, which is the previous name of Ro Custom Rx Treatment—the formulas did not change when the product was renamed. The members received their treatment at no cost for offering their photos and/or testimonials.
  • "I feel so much better and I've had a major confidence boost."

  • “I would recommend because the skincare products are AFFORDABLE, the customer service and doctors are AWESOME, and last but not least, you will have A+ skin.”

  • "I was spending so much on OTC skincare and not getting the results I wanted, and I decided to try Ro to get scrip strength without all the visits and hassle."

  • “I notice [my] skin is shining more like it used to when I was in my 20s. I feel more confident in my everyday life and I don’t wear as much makeup now that my skin looks better.”

  • “My skin has drastically changed. It's more clear, no new skin feels fresh!”

  • “Incredible. I have my skin back, along with my confidence!”

  • “I'm 49 and people say my skin looks 28.”

  • “I know tretinoin and niacinamide can take several months to notice results, but in the 3 months I’ve been using it I’ve noticed results. My pores are smaller and look less clogged. My skin texture is smoother.”

  • “I was amazed at how quickly I received my order and how helpful my doctor has been.”

  • “My skin has improved so much since using this product.”

  • “Trustworthy, convenient, personalized care!”

25% off your first order, if prescribed

Custom Rx Treatment: $43/first order

Pair this with your treatment for instant and 24-hour hydration

Enriching Cream: +$12/first order

After your first order, you will automatically be shipped a new order and billed every 2 months—$58 for Custom Rx Treatment and $16 for Enriching Cream—until you cancel. If you do the math, the trial offer is slightly more than 25% off—that’s on purpose, because we like round numbers and we like you.

Real results in real time

You may experience some side effects—like dryness, redness, or peeling—but there’s no need to panic. It’s a sign that your skin is adjusting to your treatment. Your provider may recommend using more moisturizer than normal (or even diluting your treatment with moisturizer) during this process, and reaching out to them with questions.

Be sure to follow safety measures, like applying sunscreen, refraining from waxing, and avoiding medications known to cause sun sensitivity.

By now, your skin has started acclimating to your treatment. You may still be experiencing side effects, but not to worry. Stay consistent with your moisturizer, and continue applying your treatment as directed by your provider.

Your mirror isn’t playing tricks on you—this is when most people start noticing visible improvements in their skin. These results could include a more even skin tone, faded blemishes, smoother skin texture, and an overall glow. If you have any concerns (or want to share your progress), reach out to your provider.

You’ve made looking (and feeling) good a habit. You may notice improved skin firmness and reduced fine lines and wrinkles. Stick with your routine—your skin may continue to improve over months and even years.

Remember! Your Custom Rx works best as a long-term treatment to help you achieve and maintain your skin goals.

Tap into custom care

You’re not on your skincare journey alone. Your provider will follow up on your progress, help you manage side effects, and as your skin evolves, adjust your treatment as needed to optimize results.

Dermatologist-designed, free, 10-minute online visit

Custom Rx Treatment tailored to your goals, if prescribed

Free and unlimited check-ins

Confidence in your skin and your skincare


Custom Rx Treatment is a customized skincare treatment intended to be used on the face. It’s a compounded drug product, which means it’s a mixture of different ingredients selected based on your specific needs. While compounded medications are not FDA-approved, they serve an important patient need—especially when FDA-approved medication is not available for treatment.

Our team of experts, including dermatologists and our very own Chief Medical Officer, created the Custom Rx Treatment formulations and Enriching Cream, a 24-hour moisturizer, to pair with it.

If prescribed, several different ingredients may end up in your formulation of Custom Rx Treatment. Through Ro, you’ll be connected with a US-licensed healthcare professional who will select the most appropriate combination of ingredients, tailoring the formulation to your specific skin concerns and goals. You’ll receive information about the ingredients in your formulation in your treatment plan.

Custom Rx Treatment is made with a blend of ingredients that were hand-selected by a dermatologist and customized to fit your needs. Depending on your specific skin type, concerns, and goals, the ingredients in your Custom Rx Treatment may include:

If prescribed, you will receive a detailed treatment plan that describes which ingredients are included in your custom formulation.

Custom Rx Treatment is tailored to target a wide range of skin concerns. These include:

  • Dark spots

  • Fine lines and wrinkles

  • Acne

  • Clogged pores

  • Discoloration

  • Uneven skin tone

  • Skin firmness

  • Skin texture

  • Inflammation

  • Redness

  • Dryness

  • Dullness

During your online visit, you will be asked about your specific skin goals, including which concerns you’d most like to address. If prescribed, your bottle of Custom Rx Treatment will include ingredients that are selected based on the concerns and goals you’ve indicated.

When using Custom Rx Treatment, the timing of the effects of your treatment will be dependent on many factors, including your specific skincare goals (e.g., reducing the appearance of fine lines and wrinkles, reducing redness, etc.), how severe your symptoms are, how well you tolerate the treatment, and others. It is also important to understand that—for certain treatments—your skin may appear worse before it gets better. Depending on the treatment you are prescribed, you will receive detailed information on the formulation, what to expect and when, as well as tips on how to mitigate any side effects such as redness, peeling, and flaking that may occur as your skin acclimates to the treatment.

In many cases, yes. Depending on your specific treatment, your provider may recommend avoiding skincare products with ingredients such as salicylic acid, glycolic acid, or benzoyl peroxide—at least during the beginning weeks of treatment. If you have any questions about specific products, you can message your provider for guidance. If you’re using other topical prescription medications, make sure to tell your provider.

Prescription skincare can make your skin more prone to irritation and sensitivity to the sun. To help with dryness, Ro offers Enriching Cream, a rich yet non-greasy moisturizer that enhances your Custom Rx Treatment routine. It’s tested to deliver instant and 24-hour hydration, helps support the skin barrier, and reduces the look of both dryness and flakiness for skin that feels softer and smoother.

Of course we recommend using broad-spectrum sunscreen with an SPF of at least 30 every day.

Still have questions?

Visit the FAQs page

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