Take 25% off your first order Start Now

Custom Rx Treatment

from $58Sale price $43/2 months 25% off first order

Meet the award-winning Custom Rx Treatment. Prescription skincare customized for your skin type and skin goals....

US-licensed healthcare providers

Free shipping

Billed and shipped every 2 months

Tap into custom care

Dermatologist-designed, free, 10-minute online visit

Custom Rx Treatment tailored to your goals, if prescribed

Confidence in your skin and your skincare

Your routine, your way

Set your skin up for success with dermatologist-backed picks.

Enriching Cream

Moisture-locking. Barrier-supporting. Skin-nourishing.


Quench your skin’s thirst. Tested to deliver instant and 24-hour hydration, this rich yet non-greasy moisturizer enhances your Custom Rx Treatment routine. It helps support the skin barrier, and reduces the look of both dryness and flakiness for skin that feels softer and smoother.

Only available with Custom Rx Treatment

Billed and shipped every 2 months

Hydrating Cleanser

Invigorating. Non-lathering. Deeply-cleansing.


Start your AM and PM skincare routines with a clean slate. This creamy gel facial cleanser washes dirt, oil, and environmental pollutants away, leaving your skin feeling nourished.

Only available with Custom Rx Treatment

Billed and shipped every 2 months

Protecting SPF Lotion

UVA- and UVB-protecting. Lightly hydrating ingredients.


This broad spectrum SPF 28 sunscreen offers daily protection for your skin. Apply it every single day, rain or shine, as the last step in your morning skincare routine. For extended sun exposure, broad spectrum SPF 30+ is recommended. Your skin will thank you.

Only available with Custom Rx Treatment

Billed and shipped every 2 months


Our version of show (or glow) and tell: See photos of real Ro patients throughout their skincare journey (after at least 6 months of treatment on Custom Rx Treatment).

Before & after (4 weeks)

Meet Bailey and her journey with Custom Rx Treatment

"I feel so much better and I've had a major confidence boost."


Acne. Dark spots.

Your goals are our goals, and we love hearing about how things are going*

  • "I was amazed at how quickly I received my order and how helpful my doctor has been "

    Ro Derm member

  • "I know tretinoin and niacinamide can take several months to notice results, but in the 3 months I’ve been using it I’ve noticed results. My pores are smaller and look less clogged. My skin texture is smoother."

    Ro Derm member

  • "I'm 49 and people say my skin looks 28."

    Ro Derm member

  • "Incredible. I have my skin back, along with my confidence!"

    Ro Derm member

  • "My skin has drastically changed. It's more clear, no new breakouts, visibly less scarring...my skin feels fresh!"

    Ro Derm member

  • "Trustworthy, convenient, personalized care!"

    Ro Derm member

*These testimonials were submitted by verified members for Rory Nightly Defense, which is the previous name of Ro Custom Rx Treatment—the formulas did not change when the product was renamed. The members received their treatment at no cost for offering their photos and/or testimonials.

Dermatologist-selected, science-backed ingredients

Depending on your prescription, your Custom Rx Treatment may contain:

  • Tretinoin

    Acne, uneven skin tone and texture, fine lines and wrinkles, dark spots, clogged pores, dullness
  • Niacinamide

    Acne, inflammation, blemishes, uneven skin tone
  • Azelaic acid

    Acne, inflammation, blemishes, uneven skin tone
  • Tranexamic acid

    Dark spots, discoloration, uneven skin tone
  • Vitamin E

    Dryness, uneven skin texture
  • Hyaluronic acid

    Dryness, dullness
25% off your first order, if prescribed

Custom Rx Treatment: $43/first order

Complete your routine with dermatologist-backed products.

Enriching Cream: +$12/first order

Hydrating Cleanser: +$9/first order

Protecting SPF Lotion: +$9/first order

After your 25% off first order trial, you will be billed - $58 for Custom Rx Treatment, +$16 for the Enriching Cream, +$12 for Hydrating Cleanser, +$12 for Protecting SPF Lotion - until you cancel.

Free and unlimited check-ins

You’re not on your skincare journey alone. Your provider will follow up on your progress, help you manage any side effects, and, as your skin evolves, adjust your treatment as needed to optimize results.


Custom Rx Treatment is a customized skincare treatment that is intended to be used on the face. It is a compounded drug product, which means it is a mixture of different ingredients that are each selected based on your specific needs. While compounded medications are not FDA-approved, they serve an important patient need—especially when FDA-approved medication is not available for treatment.

Our team of experts, including dermatologists and our very own Chief Medical Officer, created the Custom Rx Treatment formulations and selected a cleanser and SPF lotion to complement them.

If prescribed, there are several different ingredients that may end up in your formulation of Custom Rx Treatment. Through Ro, you’ll be connected with a US-licensed healthcare professional who will select the most appropriate combination of ingredients, tailoring the formulation to your specific skin concerns and goals. You will receive information about the ingredients in your formulation in your treatment plan.

Custom Rx Treatment is made with a blend of ingredients that were hand-selected by a dermatologist and customized to fit your needs. Depending on your specific skin type, concerns, and goals, the ingredients in your Custom Rx Treatment may include:

  • Tretinoin

  • Azelaic acid

  • Niacinamide

  • Vitamin E acetate

  • Tranexamic acid

  • Ceramides

  • Hyaluronic acid

If prescribed, you will receive a detailed treatment plan that describes which ingredients are included in your custom formulation.

Custom Rx Treatment is tailored to target a wide range of skin concerns. These include:

  • Fine lines and wrinkles

  • Acne

  • Clogged pores

  • Dark spots

  • Discoloration

  • Uneven skin tone

  • Skin firmness

  • Skin texture

  • Inflammation

  • Redness

  • Dryness

  • Dullness

During your online visit, you will be asked about your specific skin goals, including which concerns you’d most like to address. If prescribed, your bottle of Custom Rx Treatment will include ingredients that are selected based on the concerns and goals you’ve indicated.

When using Custom Rx Treatment, the timing of the effects of your treatment will be dependent on many factors, including your specific skincare goals (e.g., reducing the appearance of fine lines and wrinkles, reducing redness, etc.), how severe your symptoms are, how well you tolerate the treatment, and others. It is also important to understand that—for certain treatments—your skin may appear worse before it gets better. Depending on the treatment you are prescribed, you will receive detailed information on the formulation, what to expect and when, as well as tips on how to mitigate any side effects such as redness, peeling, and flaking that may occur as your skin acclimates to the treatment.

In many cases, yes. Depending on your specific treatment, your provider may recommend avoiding skincare products that have ingredients such as salicylic acid, glycolic acid, or benzoyl peroxide—at least during the beginning weeks of treatment. If you have any questions about specific products, you can message your provider for guidance. If you are using other topical prescription medications, make sure to tell your provider.

Prescription skincare can make your skin more prone to irritation and sensitive to the sun, so Ro offers its own dermatologist-selected skincare products to complement your treatment: its refreshing Hydrating Cleanser and its UVA/UVB broad-spectrum sunscreen, Protecting SPF Lotion. For those engaging in extended outdoor activity, a stronger broad-spectrum sunscreen with an SPF of at least 30 is recommended.

Still have questions?

Visit the FAQs page

Discover more

Your routine, your way

Set your skin up for success with dermatologist-backed picks.

  • Custom Rx Treatment

    High-performing. Goal-targeting. Award-winning.

  • Enriching Cream

    Moisture-locking. Barrier-supporting. Skin-nourishing.

  • Hydrating Cleanser

    Invigorating. Non-lathering. Deeply cleansing.

  • Protecting SPF Lotion

    UVA- and UVB-protecting. Lightly hydrating ingredients.