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Over 1,000,000+ Ro members

Fast-acting cold sore treatment

Valacyclovir for cold sores at $14/outbreak* (on a recurring plan), if prescribed

100% online with no in-person visit

Medical provider will get back to you within 24 hours

Free online visit

Outbreaks and preventative treatments available

*Dosing minimums apply; total cost varies based on dosing regimen and shipping frequency. See pricing details here.

Cold Sores pills in Ro bottle and happy people using the medication

About cold sores and ways to treat it

Cold sores are caused by the herpes simplex virus (HSV), a very common virus that lives in the body for life after infection. The herpes simplex virus transfers easily between people through normal human interactions, like sharing unwashed utensils or cups, touching a sore before it’s healed, or kissing. Once infected with HSV, people can get cold sores outbreaks repeatedly. There is currently no cure for HSV. However, there is some good news! Cold sores treatments are available, such as antiviral medications, that can help prevent and resolve outbreaks from occurring.

There are many lifestyle and health factors that can trigger a cold sore outbreak, like a weakened immune system, lack of sleep, and stress - just to name a few. The first sign of a cold sore is often a tingling or burning sensation in the breakout area. This is followed by a small, red bump. The bump fills with fluid before blistering. Eventually the blister breaks and crusts over. The entire process, from the first sign of a cold sore to the healing of the crust, can take about two weeks.

Thankfully, there’s ways to help manage cold sores. Prescription oral antiviral medications like valacyclovir (generic Valtrex) can be an effective cold sores treatment. It works best when you take it immediately after the first symptoms appear. Taking antiviral medications within the first 24 hours of symptoms can shorten how long outbreaks last.

Fast-acting treatment for cold sores

Depending on how frequently you have outbreaks

Cold Sores Genital Herpes Valacyclovir in Ro bottle

Occasional outbreaks


Starting at $14/month on a recurring plan*

When taken at the first signs of an outbreak, valacyclovir can shorten how long cold sores last. Learn more about valacyclovir.

Get started

Your first herpes outbreak should be diagnosed by an in-person medical provider.

Cold Sores Genital Herpes Valacyclovir in Ro bottle

Frequent outbreaks


Starting at $29/month on a recurring plan*

Valacyclovir can be taken daily (prescribed off-label) to reduce the chance of outbreaks. Learn more about valacyclovir.

Get started

Your first herpes outbreak should be diagnosed by an in-person medical provider.

How Ro works

  1. man smiling


    Online visit

    Share your symptoms and medical history in the free online visit. A US-licensed healthcare provider will review your information and will typically get back to you within 24 hours.

  2. Discreet packaging with Ro logo


    Free and discreet deliveries

    If prescribed, your treatment will arrive at your door in discreet packaging.

  3. Work with your Ro-affiliated provider to find the best treatment plan for your lifestyle.


    Ongoing care

    Send your provider a message at any time to discuss updating your treatment, address side effects, or answer other treatment-related questions or concerns.

From the experts at Ro

Learn more about cold sores

FAQs about treating cold sores (oral herpes)

Ro is a telemedicine company that provides a discreet, convenient, and affordable way to receive prescription cold sore treatment from a provider—all without leaving the couch. It starts with an online visit. The online visit will ask about your symptoms, medical history, and other basic information. You'll also be asked to upload your ID photo to verify your identity. A provider will review your information to determine if you're a candidate for treatment through telemedicine and craft a personalized treatment plan for you.

Ro-affiliated healthcare providers prescribe valacyclovir (generic Valtrex) to treat cold sores (oral herpes). When used properly, this medication can abort an outbreak at the first sign that one is coming on or lessen its severity.

Cold sore (oral herpes) medication is available, and it works extremely well. But it requires you to dedicate the time to learn about your condition and work with your provider to craft the ideal, personalized treatment plan.

When you do, you can identify your specific symptoms (prodrome) and use your medication to shorten or stop the outbreak from occurring.

Your provider may prescribe valacyclovir as a daily treatment to prevent cold sores. This is an off-label use of the drug, which means that the FDA hasn’t approved valacyclovir as a suppressive treatment for cold sores. Healthcare professionals are allowed to prescribe FDA-approved medications for off-label uses if they think it is the best course of treatment for their patients. If you have questions about using valacyclovir for cold sore suppression, talk to your provider.

You may wonder if home treatments and treatments can relieve your cold sore symptoms and make the often painful blisters around the mouth go away quicker. These home cold sore remedies may include lip balms, using cold tea bags as a compress, or applying ice to soothe the area and ease pain. While these home remedies can help to alleviate some cold sore symptoms, such as reducing swelling, there's no evidence that they make cold sores go away faster. The most effective and proven treatment for cold sores. Taking this medication right after noticing the first cold sore symptoms can shorten the outbreak’s length.

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