Important safety information
What you should know before taking Zepbound.
Tirzepatide (same active ingredient as Mounjaro®), for weight loss
Zepbound® (tirzepatide) Injection
Lose 20% of your body weight on average in 1 year*. See safety info below.
New FDA-approved medication for weight loss (same active ingredient as Mounjaro)
Targets two hormone receptors (GLP-1 and GIP) to maximize weight loss
What is Zepbound?
Zepbound contains tirzepatide—the same active ingredient as Mounjaro®. It’s an FDA-approved GLP-1 for weight loss in adults with obesity, or overweight with a weight-related condition, alongside diet and exercise. Zepbound is now available as a multidose KwikPen or as a single-dose autoinjector pen.
How is Zepbound different from Ozempic® or Wegovy®?
Zepbound and Wegovy are approved by the FDA for weight loss, while Ozempic is approved for the treatment of type 2 diabetes, but can be prescribed off-label for weight loss, if appropriate.
The main difference between these medications is the active ingredient. Ozempic and Wegovy contain semaglutide, while Zepbound contains tirzepatide. Tirzepatide is a dual-action GLP-1 and GIP, meaning it works by activating two receptors. In comparison, semaglutide activates the GLP-1 receptor only. Both Zepbound and Wegovy curb hunger and regulate your appetite, helping you feel fuller faster and for longer.
What are the side effects of Zepbound?
The most common side effects of Zepbound are: nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching/gas, hair loss, and heartburn.
Zepbound may have serious side effects, including possible thyroid tumors. Do not use if you or your family have a history of a type of thyroid cancer called MTC or MEN 2.
Zepbound may cause other serious side effects, including severe gastrointestinal disease, kidney injury, gallbladder disease, inflammation of the pancreas, severe allergic reactions, low blood sugar, complications in patients with diabetic retinopathy, and suicidal thoughts. Zepbound may reduce the efficacy of birth control pills.
Your Ro-affiliated provider will work with you to manage any side effects.
See full Important Safety Information here.
*Patients without diabetes and with BMI ≥30, or BMI ≥27 plus a weight-related condition, lost an average of 20% of their body weight by 1 year in a 72-week trial studying the highest maintenance dose of Zepbound (15 mg), when paired with diet and exercise changes (compared to 3% with diet and exercise alone).
Select your current weight
252lbs
Weight you could lose (lbs):
50lbs
Based on manufacturer trials studying the highest doses of Wegovy and Zepbound in non-diabetics with obesity, or with overweight plus a weight-related medical condition, when paired with diet and exercise changes (vs ~2-4% with diet and exercise alone).
Your timeline to treatment
From personalized treatment to insurance support, we help you get—and stay—on track.
Start losing weight in 5 simple steps
1. Start your online visit
Answer a few questions about your health and goals, all online—no in-person doctor’s office visit necessary. You’ll find out if you’re eligible within 2 days.
2. Provider writes an Rx (if appropriate)
A provider will review your info and prescribe the right GLP-1 treatment for you, if eligible. Get ready for your first dose in 1-2 weeks if paying cash, or 2-3 weeks if using insurance.
3. Check your insurance coverage
Ro checks your insurance to see if GLP-1 coverage is available. If you require prior authorization, Ro's insurance concierge fights for coverage and submits all paperwork on your behalf. If you're covered, a prescription is sent to your pharmacy. If not, your provider will suggest alternative FDA-approved cash pay GLP-1 options. This process takes about 2-3 weeks.
4. Start your treatment
If paying cash, your medication ships right to your door and you can take your first dose in less than a week. If using insurance, your medication can be picked up at your pharmacy.
5. Get support to stay on track
Keep making progress with regular check-ins, expert guidance, and access to your care team 24/7. Ongoing care and support is there for you when you need it—whether it’s a quick chat with your provider or routine check-ins, we’re with you every step of the way.
Dr. Pepper lost 30 lbs in 1 year
“I started losing weight almost immediately. To me, truly, this has been a game-changer.”
Dr. Pepper Ro Ambassador who inspired the Body Program, after taking GLP-1 medication
Stacie lost 49 lbs in 6 months
“I used to constantly crave food in general. I was always hungry before starting the Body Program.”
Stacie Ro member after taking GLP-1 medication
Meet our experts
Ro offers access to weight loss medications and care customized to your needs and goals.
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Charles Barkley
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Hannah
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Greg
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Zepbound FAQs
Can I get Zepbound through Ro?
Yes! If you're interested in starting treatment with Zepbound—whether single-dose pens or KwikPen–the first step is completing an online visit so that a medical provider can determine if treatment is right for you. If you’re prescribed Zepbound KwikPen, it will be shipped directly to your door.
What are the common side effects of Zepbound?
The common side effects of Zepbound often improve within the first few weeks of starting treatment. Side effects may also occur when doses are increased.
Some of the most common side effects of Zepbound include:
Nausea
Diarrhea
Vomiting
Constipation
Stomach pain
Indigestion
These are not all of the possible side effects of Zepbound. Learn more about other side effects and serious warnings at ro.co/safety.
How do you store Zepbound?
Store at 36–46°F in their original carton until you're ready to use them. Pens can be kept in the fridge until the expiration date on the label.
How much does Zepbound cost?
Using insurance? Zepbound pen may be covered by insurance.
Our insurance concierge will fight for your coverage and handle all of your paperwork.
Paying cash? The Zepbound KwikPen is available as a cash pay-only offering on Ro:
$299/mo for 2.5 mg dose
$399/mo for 5 mg dose
$449/mo for 7.5 mg, 10 mg, 12.5 mg, and 15 mg doses (with manufacturer offer)
More on the manufacturer offer: LillyDirect is offering the 7.5 mg, 10 mg, 12.5 mg, and 15 mg doses of Zepbound KwikPen at a discounted $449/mo price.
To keep this discounted price for 7.5 mg, 10 mg, 12.5 mg, and 15 mg refills you must complete your next refill check-in within 45 days of your last delivery.
What happens if you miss the 45-day window? You’ll be charged the full price for your refill:
$499 for a 7.5 mg refill
$699 for 10 mg, 12.5 mg, and 15 mg refills
We'll send you reminders to complete your refill check-in as the 45-day deadline gets closer.
Learn more about pricing here.
Additional Ro Body membership fee required. The Ro Body membership fee is as low as $74/month when you prepay on an annual plan.
How is Ro helping patients navigate GLP-1 medication shortages?
Ro and Ro-affiliated providers are following GLP-1 medication shortages closely so we can support new and existing patients on their weight loss journeys.
Thanks to our new partnership with LillyDirect, you can now access Zepbound single-dose vials, which contain the exact same FDA-approved weight loss formulation as Zepbound pens. These are in stock now and if prescribed, will ship directly to your home.
From the experts at ro
Read more about Zepbound
Zepbound 101
How does Zepbound work?
Zepbound mimics two naturally occurring hormones (GLP-1 and GIP) in your body to help you regulate your metabolism. This slows digestion and makes you feel full faster and longer. It also communicates with the part of your brain in charge of hunger to help you regulate how much you eat. On average, patients lost 20% of their body weight in a year using the highest dose of Zepbound when combined with healthy lifestyle changes.
What is Zepbound’s dosing?
If prescribed, you’ll start on the lowest dose (2.5 mg) for the first four weeks, and then work with your provider to slowly increase your dose every four weeks until you reach a steady dose that works best for you.
How do you take Zepbound?
Zepbound is a once-weekly injection that comes in a pre-filled, single-dose pen. If prescribed, you’ll receive detailed instructions from your provider on how to inject it in your stomach, arm, or thigh.
How much weight can I expect to lose with Zepbound?
In clinical trials, patients lost an average of 20% of their body weight in a year when they combined the highest dose of Zepbound with healthy lifestyle changes.
Who can use Zepbound? Who shouldn’t use it?
Zepbound is approved for weight loss in adults who either have a BMI of at least 30 or a BMI of at least 27 with a weight-related condition, like high blood pressure, type 2 diabetes, or cardiovascular disease.
How are side effects for Zepbound different from Ozempic or Wegovy?
The side effects of Zepbound are similar to Ozempic and Wegovy. However, birth control pills have been shown to be less effective when taking Zepbound. If you’re considering treatment with Zepbound, tell your provider about what contraception you’re taking. For more information about side effects, learn more here: ro.co/safety-info/zepbound
Will insurance cover Zepbound?
Some health plans cover Zepbound for weight loss, but coverage and copay amounts vary. Plans may also require prior authorization before approving coverage. If you’re interested in paying with insurance, we’ll work with your provider to help you get coverage.