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If you’ve ever walked down the supplement aisle, you know there seems to be an endless amount of supplements you could take. All those choices make it difficult to know which ones you should take and what each one does.
Lysine is one of the essential amino acids with numerous health claims and different supplement options. This article covers what lysine is, what it does, its benefits, side effects, and how you can get it.
What is lysine?
Lysine is an amino acid the body needs for many different functions and processes. It’s one of the essential amino acids, which means the body can’t create it and it has to be consumed from nutrients in the diet. The other essential amino acids include histidine, isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, and valine.
The body uses amino acids to make proteins, begin reactions, and create other substances the body needs. Often, amino acids are referred to as the building blocks of protein (Meenu Singh, 2011).
L-lysine is the most common form of lysine found in supplements and foods. This form is the preferred type for making protein.
What does lysine do?
Lysine is used for many different purposes in the body, including (Meenu Singh, 2011):
- Used to create proteins
- Promotes cell and muscle growth
- Used to create carnitine
- Assists in transporting fat and lipids between cells
- Promotes collagen growth
- Used in creating enzymes, antibodies, and hormones
- Aids calcium absorption
With the many different functions of lysine, it should come as no surprise this essential amino acid has numerous health benefits. Consuming adequate amounts of lysine through your diet or dietary supplements may provide potential health benefits like:
May prevent and treat cold sores
Cold sores, also called fever blisters, are caused by the herpes simplex virus type 1 (HSV-1). Once you’re exposed to the HSV-1 virus, it always remains in the body, but it usually stays dormant and doesn’t cause any symptoms.
Sometimes, the virus will become triggered and cause cold sores to develop. Typically, a cold sore will clear up within 7–10 days without treatment. Still, the sores can be uncomfortable and annoying, so it helps to find treatments that help them clear more quickly.
How to get rid of cold sores as quickly as possible
Taking a lysine supplement may help to shorten the duration, reduce the severity, and even prevent cold sore outbreaks. It’s believed that lysine may help stop HSV-1 from reproducing so that it becomes inactive again (Thein, 1984).
One study found that taking 1,000 milligrams (mg) of lysine daily and keeping blood levels of lysine above 165 nmol/milliliter significantly decreased the number of cold sore symptoms (Thein, 1984). Another study found an ointment with lysine, zinc, and other herbs fully resolved symptoms for 40% of participants after 3 days of treatment and 87% after 6 days (Singh, 2005).
However, not all research supports the effectiveness of lysine supplements for cold sores. A 2017 study found doses of 1,000 mg per day weren’t effective for treating cold sores. But they did find that doses over 3,000 mg per day may improve people’s experience of symptoms (Mailoo, 2017).
May reduce blood pressure
Early research suggests lysine supplements may help lower blood pressure. Another 2017 study tested the effects of lysine supplements on adults with hypertension (high blood pressure). The results showed that the supplements helped lower pressure for people not consuming enough lysine through their diet (Vuvor, 2017). More research is needed to determine whether this benefit could be seen for people already consuming an adequate amount of lysine in their diet.
May help manage diabetes
Diabetes is a medical condition where the amount of sugar (glucose) in the bloodstream is too high. Uncontrolled diabetes may cause health complications like increased infections, wounds that don’t heal well, vision problems, kidney disease, and changes to nerve and blood vessel health.
A small 2017 study found that taking lysine helped slow down the increase in blood sugar after eating (Ullrich, 2017). If this effect is confirmed in larger studies, it could help keep blood sugar levels more stable throughout the day. Another study suggests lysine supplement may help manage some complications of diabetes by lowering the risk for infection (Mirmiranpour, 2016).
May support healthy muscles
Because lysine plays a role in cell turnover and growth, researchers believe it may support healthy muscle mass and strength. One study found that over 8 weeks, a high lysine diet had a small positive effect on increasing the participants’ muscle strength (Unni, 2012).
Another study found that adequate lysine, calcium, and vitamin D levels are essential for muscle mass, bone health, and lower body fat mass for young adult women (Aggarwal, 2020).
Vitamin D deficiency: symptoms, treatment, and prevention
May reduce anxiety
Adequate lysine intake may also be beneficial for reducing stress and anxiety levels.
A 2004 study found that fortifying lysine-deficient people’s diets with lysine reversed their deficiency and helped significantly reduce anxiety and lower stress (Smriga, 2004).
Another study tested the combined effects of L-arginine and L-lysine supplements. They found the supplements helped lower cortisol levels, mental stress, and anxiety (Smriga, 2007).
May promote healthy bones
As people get older, their risk for bone fractures and osteoporosis increases. Calcium deficiencies lead to bone loss, so adequate calcium intake has long been promoted as an essential step for preventing and slowing age related bone loss and osteoporosis.
Research suggests that lysine plays a role in calcium absorption and may help support healthy bones (Civitelli, 1992). Other studies suggest lysine promotes bone growth and collagen production, which may help support bone strength and density (Jennings, 2016).
Symptoms of a lysine deficiency
Without enough lysine in your diet, you could develop a lysine deficiency. Without enough lysine, the body will have problems creating proteins and completing other essential functions for your health.
Here are some of the signs and symptoms of a lysine deficiency (Civitelli, 1992; Lekkarinen, 2003; Vuvor, 2017; Yin, 2017):
- Poor concentration
- Slowed growth
- Red eyes
- Reproductive issues
- High blood pressure
Anemia: symptoms, causes, types, treatment
Foods high in lysine
The following are some high lysine foods (USDA, 2019):
- Red meats (beef and pork)
- Dairy products, like yogurt and cheese
- Beans and legumes
A nutrition supplement may help support adequate lysine intake if you’re unable to meet your needs through your diet alone. L-lysine is the form most commonly used in dietary supplements.
The recommendations for how much lysine to take vary based on the studies and use. A safety assessment completed in 2019 found that most people can tolerate up to 6,000 mg per day without any adverse effects (Hayamizu, 2019).
However, this amount is higher than most studies tested, which often tested doses ranging from 1,000 to 3,000 mg of lysine per day.
Consult with a health care professional for medical advice before starting any dietary supplements to find out what dose may be appropriate for you.
How do vitamin D and calcium work together?
Lysine side effects
There are few known side effects of taking a lysine supplement. However, any dietary supplement can cause side effects like:
- Nausea, vomiting, bloating, and upset stomach
- Gas, diarrhea, or constipation
Still, more long-term research is needed to fully understand the effects of taking a lysine supplement. We don’t know much about how lysine supplements may affect a person while pregnant or breastfeeding, so it’s generally recommended to limit supplement intake while pregnant unless approved by your healthcare provider.
- Aggarwal, R. & Bains, K. (2020). Protein, lysine and vitamin D: critical role in muscle and bone health. Critical Reviews In Food Science And Nutrition, 1–12. Advance online publication. doi: 10.1080/10408398.2020.1855101. Retrieved from https://pubmed.ncbi.nlm.nih.gov/33290094/
- Civitelli, R., Villareal, D. T., Agnusdei, D., Nardi, P., Avioli, L. V., & Gennari, C. (1992). Dietary L-lysine and calcium metabolism in humans. Nutrition, 8(6), 400–405. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1486246/
- Griffith, R. S., DeLong, D. C., & Nelson, J. D. (1981). Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy, 27(3), 209–213. doi: 10.1159/000237979. Retrieved from https://pubmed.ncbi.nlm.nih.gov/6262023/
- Hayamizu, K., Oshima, I., Fukuda, Z., Kuramochi, Y., Nagai, Y., Izumo, N., & Nakano, M. (2019). Safety assessment of L-lysine oral intake: a systematic review. Amino Acids, 51(4), 647–659. doi: 10.1007/s00726-019-02697-3. Retrieved from https://pubmed.ncbi.nlm.nih.gov/30661148/
- Jennings, A., MacGregor, A., Spector, T., & Cassidy, A. (2016). Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: evidence from discordant monozygotic twins. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 31(2), 326–335. doi: 10.1002/jbmr.2703. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832262/
- Lukkarinen, M., Näntö-Salonen, K., Pulkki, K., Aalto, M., & Simell, O. (2003). Oral supplementation corrects plasma lysine concentrations in lysinuric protein intolerance. Metabolism: Clinical And Experimental, 52(7), 935–938. doi: 10.1016/s0026-0495(03)00089-1. Retrieved from https://pubmed.ncbi.nlm.nih.gov/12870174/
- Mailoo, V. J. & Rampes, S. (2017). Lysine for Herpes Simplex Prophylaxis: A Review of the Evidence. Integrative Medicine, 16(3), 42–46. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419779/
- Mirmiranpour, H., Khaghani, S., Bathaie, S. Z., Nakhjavani, M., Kebriaeezadeh, A., Ebadi, M., et al. (2016). The preventive effect of L-Lysine on lysozyme glycation in type 2 diabetes. Acta Medica Iranica, 54(1), 24–31. Retrieved from https://pubmed.ncbi.nlm.nih.gov/26853287/
- Singh, B. B., Udani, J., Vinjamury, S. P., Der-Martirosian, C., Gandhi, S., Khorsan, R., et al. (2005). Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Alternative Medicine Review : A Journal Of Clinical Therapeutic, 10(2), 123–127. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15989381/
- Singh, M., Rao, M., Pande, S., Battu, S., Mahalakshmi. K., Dutt, R., & Ramesh, M. (2011). Medicinal uses of L-Lysine: past and future. International Journal of Research in Pharmaceutical Sciences, 2(4), 637-642. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/976
- Smriga, M., Ando, T., Akutsu, M., Furukawa, Y., Miwa, K., & Morinaga, Y. (2007). Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. Biomedical Research, 28(2), 85–90. doi: 10.2220/biomedres.28.85. Retrieved from https://pubmed.ncbi.nlm.nih.gov/17510493/
- Smriga, M., Ghosh, S., Mouneimne, Y., Pellett, P. L., & Scrimshaw, N. S. (2004). Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria. Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8285–8288. doi: 10.1073/pnas.0402550101. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420386/
- Thein, D. J. & Hurt, W. C. (1984). Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surgery, Oral Medicine, And Oral Pathology, 58(6), 659–666. doi: 10.1016/0030-4220(84)90030-6. Retrieved from https://pubmed.ncbi.nlm.nih.gov/6438572/
- Ullrich, S. S., Fitzgerald, P. C. E., Nkamba, I., Steinert, R. E., Horowitz, M., & Feinle-Bisset, C. (2017). Intragastric lysine lowers the circulating glucose and insulin responses to a mixed-nutrient drink without slowing gastric emptying in healthy adults. The Journal of Nutrition, 147(7), 1275–1281. doi: 10.3945/jn.117.252213. Retrieved from https://academic.oup.com/jn/article/147/7/1275/4743709?searchresult=1
- Unni, U. S., Raj, T., Sambashivaiah, S., Kuriyan, R., Uthappa, S., Vaz, M., et al. (2012). The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men. Clinical Nutrition, 31(6), 903–910. doi: 10.1016/j.clnu.2012.03.008. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22524975/
- US Department of Agriculture (USDA). (2019). FoodData Central. Retrieved from https://fdc.nal.usda.gov/index.html
- Vuvor, F., Mohammed, H., Ndanu, T., & Harrison, O. (2017). Effect of lysine supplementation on hypertensive men and women in selected peri-urban community in Ghana. BMC Nutrition, 3, 67. doi: 10.1186/s40795-017-0187-6. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050943/
- Yin, J., Li, Y., Han, H., Zheng, J., Wang, L., Ren, W., et al. (2017). Effects of Lysine deficiency and Lys-Lys dipeptide on cellular apoptosis and amino acids metabolism. Molecular Nutrition & Food Research, 61(9). doi: 10.1002/mnfr.201600754. Retrieved from https://pubmed.ncbi.nlm.nih.gov/28012236/
Dr. Steve Silvestro is a board-certified pediatrician and Senior Manager, Medical Content & Education at Ro.