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Dec 13, 2021
5 min read

Quercetin: what is it, benefits, side effects, dosage

Quercetin is a type of compound called a flavonoid that’s found in many edible and medicinal plants. It’s been extensively studied for its potential health benefits. These include being anti-microbial, anti-inflammatory, anti-allergy, heart-protective, and possibly cancer-fighting. In low doses, quercetin is considered safe with few side effects. Since it can affect how your body processes other medicines, it’s important to speak with your healthcare provider before taking a quercetin supplement.

Disclaimer

If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

It’s no secret that a diet rich in colorful fruits and vegetables can help you ward off a number of undesirable health conditions such as heart disease, diabetes, and cancer. But did you ever wonder where these plants got their seemingly magical abilities?

One type of health-promoting compound found in plants is called bioflavonoids. These are found naturally in many fruits and vegetables and help your body ward off free radicals and other compounds that can cause disease. One of the best-studied of these is a flavonoid called quercetin. 

Here’s what you should know about quercetin, including what it is and its potential benefits and side effects.

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What is quercetin?

Quercetin, a plant pigment, is a type of biologically active compound called a flavonoid. Flavonoids are often responsible for many plants’ bright colors and medicinal properties. Quercetin belongs to a subset of flavonoids called flavonols that the human body can’t produce (Yang, 2020; Anand David, 2016). 

This compound is present in a wide variety of plants that are commonly eaten and used as medicine. You can also take additional quercetin as a dietary supplement (Yang, 2020; Anand David, 2016).

Clinical trials have shown that quercetin has powerful antioxidant properties. Antioxidants are substances that can protect your cells from unstable molecules called free radicals that can cause disease and accelerate aging (Yang, 2020; Anand David, 2016).

Free radical damage has been implicated in illnesses such as heart disease, diabetes, and some types of cancer. Quercetin is the most effective free radical scavenger in the flavonoid family (Yang, 2020; Anand David, 2016).

Quercetin benefits

While more study is needed, quercetin and other flavonoids have been shown to have several potential positive health benefits.

Antimicrobial

Studies have shown that quercetin has a strong ability to slow the growth of both bacteria and fungi. The flavonoid quercetin stops the growth of certain bacteria by (Yang, 2020):

  • Changing or destroying the cell wall of bacteria
  • Affecting the way bacteria can produce and express proteins and enzymes
  • Preventing bacteria from being able to attach to other cells 
  • Stopping bacteria from being able to make DNA and RNA

Quercetin’s effect on fungi is not as strong as its effects on bacteria, but when combined with the anti-fungal medication amphotericin B, its activity is greatly improved (Yang, 2020).

Anti-inflammatory

Quercetin has been reported to be a long-lasting anti-inflammatory substance. These strong anti-inflammatory effects have been shown to affect several different types of cells in both animals and humans (Li, 2016).

Anti-allergy

Allergic disorders have been increasing worldwide, causing an increased demand for compounds that help to treat and prevent them. Recently, much attention has been focused on flavonoids such as quercetin due to their antioxidant and anti-inflammatory properties (Mlcek, 2016). 

Quercetin has been shown to have potentially beneficial effects on the immune system. It can prevent the release of histamine and other allergy-producing substances in the body. It has also been shown to stabilize the cell membrane of mast cells, which means that it can help treat mast cell-related disorders, such as asthma, sinusitis, and rheumatoid arthritis (Mlcek, 2016). 

Heart protective

Since as early as 1993, human studies have shown a correlation between how much flavonoids you consume in your diet and your risk of cardiovascular disease. Many experimental and human studies have shown that quercetin has vasodilating and anti-clotting properties that can potentially reduce your risk of heart disease (Serban, 2016).

There is some evidence that quercetin can help lower blood pressure. One study found significant effects of quercetin in lowering blood pressure compared to placebo, but more studies are needed to confirm the effects and the optimal dose. It’s possible that one day, quercetin might be used alongside traditional anti-hypertensive medications for added benefits (Serban, 2016).

Cancer-fighting 

Quercetin has been shown in animal studies to help treat and prevent the spread of cancer cells. These include lung, prostate, liver, breast, colon, skin, ovarian, and cervical cancers. Its anti-cancer properties come from its ability to help regulate the pathways that cancer uses to spread. The body also uses it to help encourage cancer cells to self-destruct (apoptosis) (Xu, 2019).

In addition, quercetin is an antioxidant. It helps to reduce oxidative stress that can damage the DNA in your body, helping to block one process that could otherwise lead to the development of cancer cells (Xu, 2019).

Quercetin foods

Quercetin is widely found in many fruits, vegetables, seeds, nuts, flowers, bark, and leaves. Some of the foods with the highest concentrations of quercetin include (Yang, 2020; Li, 2016; Anand David, 2016):

  • Apples
  • Berries
  • Citrus fruits
  • Brassica vegetables
  • Capers (very high concentration)
  • Grapes and red wine
  • Onions and shallots (high concentration)
  • Green tea
  • Tomatoes
  • Honey
  • Olive oil
  • Buckwheat
  • Ginkgo biloba

Together with kaempferol (another flavonol), quercetin is the most widely abundant dietary flavonoid found in plant foods, although it is generally present in only low concentrations except for a few foods (Mlcek, 2016; Anand David, 2016)

Quercetin side effects

Quercetin is generally considered to be very safe. Studies looking at 1 g/day for three months have not found any significant toxicity. Some of the side effects that have been reported include (Colunga Biancatelli, 2020):

  • Headache
  • Tingling sensations
  • Nausea
  • Vomiting
  • Sweating
  • Flushing
  • Trouble breathing (with high dose intravenous administration)
  • Kidney problems (with high dose intravenous administration)

It is important to remember that quercetin can change how your body processes other medications, sometimes making them less effective. Make sure to check with your healthcare provider before taking quercetin with prescription (or non-prescription) medications.

You should also not take additional quercetin supplements (the quercetin in food is fine) if you are pregnant or breastfeeding. We don’t have any information about whether this is safe or not (Colunga Biancatelli, 2020).

Quercetin dosage

Since quercetin is a supplement, there are no Food and Drug Administration (FDA)-approved dosages to take. Most supplement brands are typically dosed at 500–1000 mg per day. 

Quercetin has been found to have low bioavailability. This means that only a small percentage of what you take is absorbed into your system. Because of this, you will often find quercetin combined with other supplements that can help increase the amount that your body absorbs (Li, 2016).

Remember always to let your healthcare provider know if you’re taking any supplements such as quercetin.

References

  1. Anand David, A. V., Arulmoli, R., & Parasuraman, S. (2016). Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacognosy Reviews, 10(20), 84–89. doi: 10.4103/0973-7847.194044. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214562/
  2. Colunga Biancatelli, R., Berrill, M., Catravas, J. D., & Marik, P. E. (2020). Quercetin and vitamin c: an experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19). Frontiers in Immunology, 11, 1451. doi: 10.3389/fimmu.2020.01451. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318306/ 
  3. Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M. T., Wang, S., et al. (2016). Quercetin, inflammation and immunity. Nutrients, 8(3), 167. doi: 10.3390/nu8030167. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/ 
  4. Mlcek, J., Jurikova, T., Skrovankova, S., & Sochor, J. (2016). Quercetin and its anti-allergic immune response. Molecules (Basel, Switzerland), 21(5), 623. doi: 10.3390/molecules21050623. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273625/ 
  5. Serban, M. C., Sahebkar, A., Zanchetti, A., Mikhailidis, D. P., Howard, G., Antal, D., et al (2016). Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Journal of the American Heart Association, 5(7), e002713. doi: 10.1161/JAHA.115.002713. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015358/
  6. Xu, D., Hu, M. J., Wang, Y. Q., & Cui, Y. L. (2019). Antioxidant activities of quercetin and its complexes for medicinal application. Molecules (Basel, Switzerland), 24(6), 1123. doi: 10.3390/molecules24061123. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470739/ 
  7. Yang, D., Wang, T., Long, M., & Li, P. (2020). Quercetin: its main pharmacological activity and potential application in clinical medicine. Oxidative Medicine And Cellular Longevity, 2020, 8825387. doi: 10.1155/2020/8825387. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790550/