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Vaginal Estradiol Cream

Available quarterly ($180/3 mo)
A prescription cream containing plant-derived estrogen to treat vaginal dryness, including itching, burning and...


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Vaginal dryness

The science behind vaginal estradiol

Vaginal estradiol is a lower dose, local estrogen cream that’s applied directly to the vagina. Several studies have shown that vaginal estradiol is an effective treatment for vaginal dryness. Estradiol may help to restore your vaginal tissue, which helps to increase production of your natural vaginal lubrication and also strengthen and thicken the vaginal tissue. 

This rejuvenation of the vaginal tissue helps to improve vaginal dryness, burning, itching, as well as discomfort during sex. There can also be added benefits of vaginal estradiol such as improvements in urinary incontinence. The North American Menopause Society has stated that topical estrogen therapy is an effective treatment and safer than oral estrogen. If a prescription is appropriate, you’ll receive a customized dose and treatment plan from a healthcare provider.

Important safety information

What you should know before using vaginal estradiol.


Vaginal Estradiol 0.01% is a prescription cream containing plant-derived estrogen that is FDA-approved to treat the symptoms of vulvar and vaginal atrophy associated with menopause, including moderate to severe vaginal dryness (e.g., itching and burning)

Vaginal estradiol cream is not appropriate for everyone. To learn more about who should not use vaginal estradiol cream and the side effects that it may cause, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see the FAQ below regarding side effects and the important safety information for vaginal estradiol cream.

Vaginal estradiol is a cream that comes with a calibrated applicator that has markings for 1, 2, 3 or 4 grams. Use the applicator to apply the prescribed amount of cream into the vagina.

To minimize leakage of the cream, apply the medication at night before going to bed. Always follow your physician’s instructions. If you have any questions about your medication, please contact your provider on your Ro account.

Most patients tolerate vaginal estradiol well, but, as with any medication, vaginal estradiol can have side effects. Below are a few potential side effects:

• Headache • Back pain • Weight gain • Skin irritation, itching • Diarrhea • Nausea • Abdominal pain • Period cramps, vaginal bleeding • Pain in the breasts

Vaginal estradiol cream is not appropriate for everyone. Like most medications, vaginal estradiol can cause serious drug interactions and side effects that you should understand before using it for vaginal dryness. If you choose to complete an online visit through Rory, your doctor or nurse practitioner will be available to discuss side effects with you. To learn more about risks and benefits, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see important safety information.

Because it is caused by the decline of estrogen in the body, vaginal dryness tends to be a chronic condition. While other menopausal symptoms, like hot flashes or night sweats, end over time, symptoms of vaginal dryness do not.

Personal lubricants and moisturizers can be helpful to provide relief from the symptoms of vaginal dryness like burning, itching or painful intercourse—and they can be a great complement to vaginal estrogen therapy to provide additional relief during sex. However, personal lubricants and moisturizers do not treat the underlying cause of the symptoms, and their results are temporary.