In a recent episode of The Oprah Podcast, our GLP-1 ambassador Serena Williams joined Oprah for a candid discussion about her health journey. The conversation centered on Serena sharing an update on her experience with GLP-1 medication and why it’s so important to her to be open about the care and support she’s used to achieve her goals.

When one of the greatest athletes of all time speaks transparently about her health, it has the power to change the conversation. Take it from Oprah, “if Serena Williams—who’s working out 8 hours a day—cannot lose weight, something’s up. It’s the biology.”
Serena is widely recognized as powerful, disciplined, and strong—the GOAT in every sense of the word. That’s exactly why her willingness to share her story matters. By choosing to seek support with GLP-1 medication alongside high-quality care on Ro, Serena is helping dismantle the stigma that still surrounds weight loss medications.
On the podcast, Serena spoke authentically about how being on Ro has helped her make meaningful progress toward improving her health and overall wellbeing. Beyond weight loss, she shared that she feels happier, has more energy for her kids, and now “has knees like Megan”—even demonstrating it for the audience in a moment that elicited uproarious applause. The exchange underscored just how much better she’s feeling in her body since beginning her journey on Ro.

By sharing her experience, Serena is broadening the conversation around weight loss and health, reminding others that there’s strength in choosing support – including medication and care – to reach their goals. Since Serena first shared publicly that she was on Ro last August, her story has resonated deeply across the country. We’ve heard from countless people who felt inspired to take the next step in their own health journey simply because they saw someone like Serena being honest about hers.
That impact was felt during the podcast as well, including a moment featuring Sade, a Ro member who joined after seeing Serena speak openly about her experience.

At Ro, we’re proud to support Serena not only in her own health journey, but also as she continues to use her platform to normalize conversations around medication, care, and what it really means to take control of your health. Because when someone as strong as Serena Williams says it’s okay to seek support, it gives others permission to do the same.
Watch the full episode of The Oprah Podcast:
Oprah and the Oprah Podcast are not affiliated with Ro. Ro is not a sponsor of The Oprah Podcast.
Serena is a real Ro member and paid partner, and has a family investment in Ro.
For important safety information about GLP-1 medications, including the boxed warning, go to ro.co/safety.