from $83/month
Plenity is the first and only FDA-cleared weight management tool made from naturally derived building blocks. In...

Stimulant free and non-habit forming

Clinically tested and FDA cleared

Free 2-day shipping

Free, unlimited follow-ups

How it works

Plenity capsules absorb the water you drink mixed with the food you eat to make you feel full and help you eat less.

  1. Take 3 capsules

    Take 3 Plenity capsules before lunch and again before dinner.

  2. Drink 16 oz of water

    Don’t just take a sip—for the capsules to take effect, you need to drink 16 oz of water with each dose.

  3. Wait 20 minutes

    You’re ready to enjoy your meal and feel full after eating smaller portions.


Nearly 60% of study participants that were treated with Plenity achieved an average weight loss of 10% of their body weight or ~22 pounds.

Proven safety profile

A clinical study showed that Plenity is as safe and tolerable as a placebo (a capsule with inactive ingredients), with minor side effects.


Plenity is not a stimulant and there are no restrictions for how long it can be used.


Plenity is safe for use by people with or without other conditions such as hypertension, type 2 diabetes, or dyslipidemia.

Learn more about Plenity’s clinical trial—Gelesis Loss of Weight (GLOW) study

In a 24-week clinical trial called GLOW (Gelesis Loss of Weight), Plenity or placebo was given to 436 adults who were overweight or had obesity, in conjunction with diet and exercise.  The study was designed to measure: efficacy of at least 35% of individuals receiving Plenity lost ≥5% of their body weight, and a Placebo-adjusted weight loss of ≥3%.  There was no difference between placebo and Plenity in the overall incidence of adverse events.

*The percentage of responders, a co-primary endpoint, or the percentage of patients who lost ≥5% of body weight, achieved clinically meaningful weight loss with Plenity vs placebo (59% vs 42%; P=0.0008). The study did not meet the predefined weight loss super-superiority margin of 3% over placebo.

Important safety information

What you should know before taking Plenity