Plenity Treatment Plan

Your physician has reviewed your medical information and has prescribed medication for weight management. This medication is specifically intended to help you manage your weight and is NOT intended to treat any other medical conditions that you may have.

Quick facts

What is Plenity?

Plenity is a capsule containing a super absorbent hydrogel that absorbs up to 100 times its weight in water. It is FDA-cleared as an additive treatment for weight management in people with a Body Mass Index (BMI) of 25–40 to be used with a reduced calorie diet and exercise. Plenity is taken with 16 oz (2 cups) of water 20–30 minutes before lunch and dinner. The hydrated Plenity takes up room in the stomach promoting a feeling of fullness. Plenity does not get absorbed and leaves the body unchanged in a bowel movement. This decreases the risk of side effects compared to medications that get absorbed systemically.  Weight loss with Plenity takes several weeks although the effects of feeling fuller with meals may be obvious from the beginning of use. A weight loss of at least 3% body weight after 8 weeks of use is highly predictive of success, with about 85% of people losing at least 5% of their body weight after 24 weeks. You are also more likely to see results by taking Plenity as consistently as possible (that is, without missing any doses), exactly as directed below.  Studies have also demonstrated that people who consistently weigh themselves regularly are more likely to keep off the weight they lose over the long term (5-10 years and beyond). That is, if you are weighing yourself every day, you should continue to weigh yourself every day. If you are weighing yourself every week, keep weighing yourself every week.

How to use Plenity

Take three capsules (2.25 grams total) orally with 16 oz (2 cups) of water 20–30 minutes before lunch and again before dinner. Plenity use should be combined with a reduced calorie diet (at least 300 calories less than maintenance needs) and regular exercise (at least 30 minutes per day of moderate intensity exercise, like brisk walking).

Who should not use Plenity?

Plenity should not be used in the following groups:

  1. People who have had weight loss surgical procedures or gastric balloons

  2. People with a BMI of less than 25 or more than 40

  3. Pregnant and breastfeeding women

  4. People with allergies to ingredients in Plenity, including cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide

  5. People with esophageal anatomic anomalies (e.g., webs, diverticuli, rings)

  6. People with suspected digestive tract strictures (narrowing), such as patients with Crohn’s disease

  7. People with inflammatory bowel disease

  8. People with complications from prior gastrointestinal surgery that could affect how well the digestive tract functions and how quickly food moves through the digestive tract 

  9. People who have difficulty swallowing pills

  10. People with eating disorders, like anorexia nervosa and bulimia nervosa

What are the possible adverse effects of Plenity?

The most common adverse events seen with Plenity in a large clinical trial were GI (digestive system) adverse effects

  1. Diarrhea

  2. Decreased bowel movements

  3. Constipation

  4. Abdominal distention

  5. Flatulence (gas)

  6. Nausea

The following occurred at the same rate as the placebo group.

  1. Infections

  2. Nasopharyngitis 

  3. Influenza

  4. Upper respiratory infections

  5. Back pain

  6. Joint pain (arthralgia)

  7. Headache

For more information on Plenity adverse events, see the Plenity Instructions for Use.

When should I contact my Ro-affiliated physician?

Contact your Ro-affiliated physician, and all of your healthcare providers, if you experience any new symptoms after beginning Plenity. If you have any serious signs or symptoms, like, but not limited to, blood in your stool, severe diarrhea, fainting, or severe abdominal pain, please seek out emergency medical treatment.