An antidepressant is a type of drug used to help treat depression. Of the five major classes of antidepressants, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are the most commonly prescribed for first-line treatment. SSRIs help to alleviate symptoms by blocking the reabsorption of serotonin in the brain, while SNRIs block the reabsorption of both serotonin and norepinephrine. Monoamine oxidase inhibitors (MAOIs), Tricyclic antidepressants (TCAs), and atypical antidepressants make up the rest. A conversation with a healthcare provider will help them determine which may be the best for you.