Table of contents
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
When the immune system attacks healthy tissue and triggers inflammation, many symptoms—and potentially, complications—can arise. One example of an immune-mediated inflammatory condition is plaque psoriasis, a chronic skin disease that can cause large, red scales, called plaques, to appear on the skin (Badri, 2021).
Beyond the physical skin symptoms it causes, plaque psoriasis can also take a toll on someone’s mental health, even contributing to depression (Wu, 2018). That’s one reason why it’s important to seek care and treatment from a healthcare provider.
Read on to learn more about what causes plaque psoriasis, psoriasis symptoms, and various treatment options.
Take $20 off a one month trial of custom skincare
Try our personalized prescription skincare from the comfort of your home.
What is plaque psoriasis?
There are several types of psoriasis. As a whole, psoriasis is a chronic, inflammatory condition that affects the skin. The most common form of psoriasis is plaque psoriasis, and it affects 80-90% of people with psoriasis. It’s characterized by large, oval, or circular areas on the skin called plaques. Often, these plaques occur on a person’s scalp, trunk, and skin over the joints (Wu, 2017; Badri, 2021).
Symptoms of plaque psoriasis
Plaque psoriasis can affect the skin, joints, or in some cases, both (Sbidian, 2017). When it involves the skin, it’s characterized by distinct red patches called plaques covered by silvery scales and can occur on different areas of the skin. On black skin, the lesions can appear as purple patches with gray scales or as a dark brown color (Albaghdadi, 2021; Nair, 2021).
7 Eczema triggers to know and how to avoid them
Itching is common, and some people also experience soreness or pain, especially on the palms and soles of the feet. Most people experience flare-ups and relapses with plaques often recurring in the same locations (Benezeder, 2019; Badri, 2021). Nearly 80% of people with plaque psoriasis have co-occurring nail psoriasis, which leads to changes in how your toenails and fingernails look. They can get thick and change color or shape (Manhart, 2015).
Some people with this type of psoriasis also develop psoriatic arthritis, a chronic inflammation of the joints that resembles rheumatoid arthritis (Badri, 2021).
Like other types of psoriasis, plaque psoriasis is often linked to other conditions, such as cardiovascular disease. It’s not entirely clear why other diseases are linked to psoriasis, but experts think chronic inflammation, lifestyle factors, and the adverse effects of therapies might play a role (Armstrong, 2020).
It can also take a toll on people’s mental health and overall well-being. Even its localized forms can be impairing and lead to mental stress. In fact, many people with it also develop depression or anxiety (Wu, 2018).
Depression: symptoms, causes, diagnosis, and treatment
Plaque psoriasis triggers
Plaque psoriasis can be genetic, which means you may be more likely to get it if you have family members with the condition. It has a much higher prevalence in Caucasian people and is linked to specific risk factors, such as obesity, stress, alcohol, and smoking (Albaghdadi, 2017).
Some drugs can worsen plaque psoriasis, particularly antimalarials, beta-blockers, and lithium (Balak, 2017). Excessive scratching can also trigger or worsen psoriasis, and some plaque psoriasis is aggravated by sunlight (Badri, 2021).
Diagnosing plaque psoriasis
If you have scaly, red, symmetrical plaques on your skin, your healthcare provider—typically a dermatologist—may consider a plaque psoriasis diagnosis. They may also use a tool called a dermascope to take a closer look at the plaques before diagnosis.
It’s also important for a healthcare provider to examine the skin for other diseases and monitor other medical conditions that can co-occur with it, particularly heart conditions and arthritis (Oji, 2015).
Plaque psoriasis treatment
Plaque psoriasis isn’t life-threatening; however, it can be pretty challenging to treat in some cases. For example, severe cases can evolve into another subtype of psoriasis called pustular psoriasis. How a healthcare provider treats plaque psoriasis depends on the severity of the disease, such as how much of the body is covered (Clebak, 2020).
Sometimes, healthcare providers use scoring systems that measure a person’s severity, body surface area, and life quality to determine the best treatment (Oji, 2015).
Hormonal acne: causes, types, treatment
Treatments for plaque psoriasis include:
- Topical treatments: For mild or “limited” forms of psoriasis, topical treatments—or medication applied directly to the skin—may work. Common topical treatments include corticosteroids and Vitamin D analog (Vitamin D cream) (Armstrong, 2020).
- Biologic drugs: For moderate to severe psoriasis, the American Academy of Dermatology-National Psoriasis Foundation recommends biologics that target specific parts of your immune system as the first line of treatment. Examples of biologics used to treat psoriasis include etanercept, adalimumab, certolizumab, and infliximab (Armstrong, 2020). In studies, biologic drugs are more effective than placebo for treating moderate or severe psoriasis (Albaghdadi, 2017).
- Systemic therapies: Conventional systemic drugs like methotrexate are often used for various forms of psoriasis, including psoriasis of the nails and psoriatic arthritis (Nair, 2021).
- Light therapy or “phototherapy”: When topical treatments aren’t effective, some healthcare providers recommend light therapy for mild forms of psoriasis. Using ultraviolet (UV) light, light therapy targets areas of the skin affected by psoriasis. Long-term treatment with light therapy can increase the risk of skin cancer, so it’s important to discuss the risks of phototherapy with a healthcare provider (Zhang, 2018).
When prescribing treatments, medical providers will also consider the long-term side effects of plaque psoriasis treatment, especially with immuno-suppressive drugs like corticosteroids.
Plaque psoriasis prevention
It’s not possible to prevent plaque psoriasis. However, altering your lifestyle to decrease risk factors may help reduce the number of psoriasis flare-ups. For example, smoking and drinking are associated with plaque psoriasis. Losing weight may also improve plaque psoriasis and prevent future complications (Albaghdadi, 2017).
Stress rash: causes and treatments
When to see a doctor
Plaque psoriasis can affect people’s quality of life and present other medical problems. So it’s important to consult with a healthcare provider if you’re experiencing symptoms (Armstrong, 2020). Your primary care provider can work with other medical professionals, such as a dermatologist, to pinpoint the best course of treatment to improve your symptoms and well-being.
- Albaghdadi, A. (2017). Current and Under Development Treatment Modalities of Psoriasis: A Review. Endocrine, Metabolic & Immune Disorders Drug Targets, 17(3), 189–199. doi: 10.2174/1871530317666170804153751. Retrieved from https://pubmed.ncbi.nlm.nih.gov/28782467/
- Armstrong, A. W., & Read, C. (2020). Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review. JAMA, 323(19), 1945–1960. doi: 10.1001/jama.2020.4006. Retrieved from https://pubmed.ncbi.nlm.nih.gov/32427307/
- Badri, T., Kumar, P., & Oakley, A. M. (2021). Plaque Psoriasis. [Updated Aug 11, 2021]. In: StatPearls [Internet]. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK430879/
- Balak, D. M., & Hajdarbegovic, E. (2017). Drug-induced psoriasis: clinical perspectives. Psoriasis (Auckland, N.Z.), 7(7), 87-94. doi: 10.2147/PTT.S126727. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29387611/
- Benezeder, T., & Wolf, P. (2019). Resolution of plaque-type psoriasis: what is left behind (and reinitiates the disease). Seminars in Immunopathology, 41(6), 633–644. doi: 10.1007/s00281-019-00766-z. Retrieved from https://pubmed.ncbi.nlm.nih.gov/31673756/
- Clebak, K. T., Helm, L., Helm, M. F., & Seiverling, E. V. (2020). The many variants of psoriasis. The Journal of Family Practice, 69(4), 192–200. Retrieved from https://pubmed.ncbi.nlm.nih.gov/32437484/
- Greb, J. E., Goldminz, A. M., Elder, J. T., Lebwohl, M. G., Gladman, D. D., et al. (2016). Psoriasis. Nature Reviews. Disease Primers, 2, 16082. doi: 10.1038/nrdp.2016.82. Retrieved from https://pubmed.ncbi.nlm.nih.gov/27883001/
- Griffiths, C. E., & Barker, J. N. (2007). Pathogenesis and clinical features of psoriasis. Lancet (London, England), 370(9583), 263–271. doi: 10.1016/S0140-6736(07)61128-3. Retrieved from https://pubmed.ncbi.nlm.nih.gov/17658397/
- Korman, N. J. (2020). Management of psoriasis as a systemic disease: what is the evidence?. The British Journal of Dermatology, 182(4), 840–848. doi: 10.1111/bjd.18245. Retrieved from https://pubmed.ncbi.nlm.nih.gov/31225638/
- Manhart, R., & Rich, P. (2015). Nail psoriasis. Clinical and Experimental Rheumatology, 33(5 Suppl 93), S7–S13. Retrieved from https://pubmed.ncbi.nlm.nih.gov/26472140/
- Nair, P.A., & Badri, T. (2021). Psoriasis. [Updated Aug 11, 2021]. In: StatPearls [Internet]. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK448194/
- Oji, V., & Luger, T. A. (2015). The skin in psoriasis: assessment and challenges. Clinical and Experimental Rheumatology, 33(5 Suppl 93), S14–S19. Retrieved from https://pubmed.ncbi.nlm.nih.gov/26472560/
- Sbidian, E., Chaimani, A., Garcia-Doval, I., Do, G., Hua, C., et al. (2017). Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. The Cochrane Database of Systematic Reviews, 12(12), CD011535. doi: 10.1002/14651858.CD011535.pub2. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29271481/
- Wu, J. J. (2017). Contemporary management of moderate to severe plaque psoriasis. The American Journal of Managed Care, 23(21 Suppl), S403–S416. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29297664/
- Wu, J. J., Feldman, S. R., Koo, J., & Marangell, L. B. (2018). Epidemiology of mental health comorbidity in psoriasis. The Journal of dermatological treatment, 29(5), 487–495. doi: 10.1080/09546634.2017.1395800. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29057684/
- Zhang, P., & Wu, M. (2018). A clinical review of phototherapy for psoriasis. Lasers in Medical Science, 33(1), 173-180. doi: 10.1007/s10103-017-2360-1. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29067616/