(oxymetazoline hydrochloride ophthalmic solution), 0.1%

Ro no longer offers Upneeq. If you're interested in other eye-enhancing treatments, Ro offers Latisse, an FDA-approved eyelash growth treatment. Upneeq is the only FDA-approved prescription eye drop proven to temporarily lift upper eyelids and treat ptosis (droopy eyelids) for an awake, refreshed look.

See a lift in as little as 5 mins (full effects at 2 hours)*

Lasts 6-8 hours

Non-invasive eyelid lift

Eye-opening transformations

  • Before and after using Upneeq product

  • Before and after using Upneeq product

See Upneeq love in action

These testimonials were submitted by verified Ro members who were prescribed Upneeq. The members were compensated and received their treatment at no cost for offering their photos and testimonials.

The lowdown on Upneeq*

of patients had some form of improvement in the lifting of their eyelids at 2 hours

See the difference:

Average upper eyelid lift in clinical trials was 1 mm.

Fast acting, long lasting:

Lifts eyelids in as little as 5 minutes after application (with full effects seen at 2 hours), and lasts up to 8 hours.


of patients had more than 50% improvement

*Data from a pooled analysis of two 6-week, randomized, double-masked, placebo-controlled multicenter clinical trials.

How to apply Upneeq

Woman using Upneeq product

01 Drop

Put one drop in each affected eye, as directed. If you wear contacts, be sure to remove them first (you can put them back in 15 minutes after application).

woman with her eyes closed

02 Chill

Close your eyes for 60 seconds after application for best results.

Some people see a lift in as little as 5 minutes, but it may take 2 hours to see full results.

Woman with Upneeq treated eyes

03 Live it up

Enjoy your bright, bold, revitalized eyes! Results last 6–8 hours.

What are low-lying eyelids?

If you’ve noticed that your eyes look tired—more tired than you feel—you may have acquired blepharoptosis (low-lying lids), also called ptosis. With this condition, the upper eyelids droop, most commonly because of progressive weakening of the eyelid muscles over time. Acquired ptosis may make you look sleepy or even obstruct your vision as it progresses.

All images are actor portrayals unless otherwise stated.

Important Safety Information for Upneeq®

What you should know before using Upneeq.

Questions? Let us help.

Upneeq® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eye drop used to treat acquired ptosis in adults.

Acquired ptosis, also known as low-lying lids, is a common condition that occurs when the muscles in the eyelid stretch and weaken, causing the top eyelid to drop.

Acquired ptosis affects adults of all ages, but occurs more often with increased age. Acquired ptosis can also be a result of cataract surgery, contact lens wear, or an underlying medical condition. It’s not uncommon for patients to have acquired ptosis in only one eye or in one eye more than the other.

Yes, Upneeq is the only FDA-approved prescription eye drop for acquired ptosis (low-lying lids). Upneeq was proven to be safe and effective when used as directed in clinical trials.

Common side effects (seen in 1–5% of patients) included eye inflammation, eye redness, dry eye, blurred vision, instillation site pain, eye irritation, and headache. For full safety information, see Important Safety Information.

Apply Upneeq to your affected eye(s) in two easy steps:

  • Step 1: Cut open the foil wrapper and remove the single-use vial

  • Step 2: Instill one drop of Upneeq in each affected eye as directed, once a day

    • Close each eye for 60 seconds post-application for the best results

    • Do not let the tip of the vial touch your eye or any other surface. Vials should not be re-used after opening and should be thrown away after applying drop(s)

If you wear contact lenses, remove them before instilling Upneeq eye drops. You may put them back in 15 minutes after administering Upneeq.

If more than one medication or eye drop is being used in the eye, they should be administered at least 15 minutes apart.

Watch a tutorial here

Patients see maximum results within 2 hours, but results may be seen as soon as 5–15 minutes.

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