5 ways to increase weight loss on Wegovy

GLP-1 medications like Wegovy have become extremely popular in the last few years, and for good reason—in clinical trials, Wegovy (semaglutide) helped people lose up to 15.8% of their body weight. 

Despite these impressive outcomes, experts warn that Wegovy is not a quick fix that works in isolation. In clinical trials and real-world use, GLP-1 therapies tend to work best when combined with consistent healthy lifestyle habits. 

If you’re wondering how to lose weight on Wegovy and get the most out of your treatment, this guide can help. From optimizing nutrition to managing stress, read on for five ways to increase weight loss on Wegovy. 

One of the key ways that semaglutide works for weight loss is by suppressing appetite, which may also reduce your food intake. Because you’re likely consuming fewer calories overall while taking Wegovy, it's essential to eat a balanced, nutritious diet that fuels your body. 

“The goal with your diet while on Wegovy is to try to pack nutrient-dense foods into your day with a specific focus on protein and fiber. These foods not only contain the vitamins and minerals you need to stay healthy, but they also support weight loss,” says Ana Reisdorf, MS, RD.

“Sometimes when our appetite is suppressed, it is tempting to just not eat, but this can backfire, resulting in slowed weight loss,” she adds.

Reisdorf, who is also a GLP-1 user, recommends eating a variety of foods while taking the medication, including:

• Lean proteins (chicken, fish, tofu)

• Fiber-rich vegetables (leafy greens, broccoli)

• Whole grains (quinoa, brown rice, oats)

• Healthy fats (avocados, nuts, olive oil)

• Low-sugar fruits (berries, apples)

She also suggests avoiding processed foods, excessive sugar, and high-calorie foods because they can potentially make the digestive side effects of Wegovy worse and may lead to weight gain. 

“A balanced diet also helps you gain healthier habits, which increases the likelihood you will maintain the weight you have lost even if the medication is discontinued,” she says.

Try these tips to help support your nutrition goals while taking Wegovy:

• Keep healthy snacks on hand. Prepare meals or ingredients ahead of time to avoid impulsive food choices.

• Practice mindful eating. Eat slowly and chew food thoroughly to learn how to recognize when you’re full.

• Hydrate. Hydration supports overall health and metabolic function, and may also support weight loss. The amount of water you should drink each day varies based on activity level, body type, and where you live. You can use body signals —such as thirst cues or even the color of your urine—to help gauge your personal fluid needs.

Physical activity can play a vital role in enhancing Wegovy's effectiveness for weight loss. Regular exercise can help burn calories, build muscle, and boost your metabolic rate. 

“The focus should not just be about burning calories. It’s about building strength, preserving muscle mass, and improving cardiovascular health,” says Dalia Beydoun, MS, RD, founder of DSB Nutrition. 

“For workouts, aim for a mix of strength training and cardio,” she says. “Aim for at least 150 minutes of moderate-intensity physical activity per week, with two sessions consisting of strength training.”

Get started with these workout ideas:

Cardio 

• Walking. Start with 10-minute walks and gradually build to 30 minutes.

• Swimming. Try 15 minutes of lap swimming.

• Dancing. Put on some music and move for 20-30 minutes, or find a cardio dance video on YouTube.

• High-intensity interval training (HIIT). Try out a 10-15-minute HIIT circuit for an efficient workout you can do at home. 

Strength training 

• Bodyweight exercises. Moves like push-ups, squats, and lunges do not require equipment and can effectively target different muscle groups. 

• Resistance bands. Exercise bands are perfect for home workouts and can help with muscle building and mobility. 

• Weight training. Start with light weights that you can lift comfortably for 10-12 reps, and focus on proper form before moving up to the next weight. 

• Core work.  Planks, leg raises, and bridges can help strengthen your body’s foundation.

Low-impact exercises 

• Water aerobics.  Water fitness provides resistance training and can improve cardiovascular fitness and strength while being easy on joints.

• Yoga. While it’s not an intense calorie burner, yoga can help improve flexibility and strength while reducing stress.

• Cycling. Use a stationary bike or cycle outdoors, beginning with 15-20-minute sessions, to help build endurance and strength. 

Whether you’re new to working out or restarting a fitness routine, set realistic goals that align with your schedule and fitness level to help build a foundation for an active lifestyle. 

Take a look at your daily routine and block out time when you can exercise each week—treat your workouts like appointments. You can also track your activity through a fitness app or journal to help monitor your progress and identify what works for your body. 

Most importantly, find activities that you like! You’re more likely to keep up with a routine if it doesn’t feel like a chore. Ultimately, the best exercise for weight loss is the kind you can stick to on a regular basis.

Stress is an often-overlooked factor that can impact weight loss (or gain). 

“Stress and lack of sleep can impact your weight loss efforts, even when using Wegovy,” Beydoun says. “ Stress can sometimes lead to emotional eating or cravings for less nutrient-dense foods, which don’t fill you up and leave you missing out on important nutrients.”

Small amounts of stress here and there can be good for you—it can make you feel more motivated and even help you respond quickly in dangerous situations. But ongoing or chronic stress can increase cortisol levels, which may contribute to weight gain by increasing cravings for high-calorie foods and promoting abdominal fat storage (especially visceral fat).

Practical ways to manage stress include:

• Just breathe. Pausing to take slow, controlled breaths can help decrease anxiety. 

• Pick up low-stakes hobbies. Make time for things you enjoy, such as listening to music, reading, or spending time in nature.

• Take digital breaks. Constant connectivity and social media use can increase stress and anxiety. Use an app to help limit the amount of time you spend on your phone, or block out “screen-free” times each day. 

• Move your body. Research shows physical activity can improve your mental health—even a short daily walk can have massive health benefits.

• Set boundaries. Say "no" to things that add unnecessary stress to your life. 

• Look for support. Whether through a mental health professional, family, or friends, having someone to talk to about your challenges can help provide relief and perspective.

Managing stress is not about eliminating it completely—that's unrealistic. Instead, focus on developing ways to cope that support your health and wellbeing.

Research shows that lack of sleep can increase ghrelin (hunger hormone) and reduce leptin (fullness hormone), making it harder to control appetite and maintain weight loss. When you're taking Wegovy, getting sufficient sleep can help optimize the medication's effectiveness by supporting your body's natural weight regulation processes.

“Poor sleep can affect hunger and fullness hormones, making it harder to stick to healthy eating habits,” Beydoun says. “It can also drain your energy, making sticking to your exercise routine more difficult.”

While the amount of sleep you need varies from person to person, most experts recommend that adults aim to get 7-9 hours of sleep a night. The quality of sleep you're getting also matters. Uninterrupted, deep sleep can help your body remove toxins from the brain and can help balance certain hormones that impact appetite and stress.

Try these strategies to improve your sleep quality:

• Stick to a sleep schedule. Go to bed at the same time each night and get up at the same time each morning—even on weekends. 

• Optimize your sleep environment. Keep your bedroom cool, dark, and quiet. 

• Put away or turn off your screens. Aim to go screen-free at least 30 minutes before bedtime. 

• Avoid large meals, caffeine, and alcohol close to bedtime. If you need a snack, opt for light, protein-focused options like yogurt, a smoothie, or roasted nuts.

It’s important to follow your healthcare provider’s recommended dosing schedule for Wegovy, which typically starts at the lowest dose and may gradually increase every four weeks, depending on your progress and how well you tolerate Wegovy.

“Providers can monitor potential side effects and adjust the dosing schedule to reduce side effects while optimizing results,” Reisdorf says. 

“The dose of Wegovy is increased gradually each month, but I personally recommend speaking to your provider about staying on the same dose until you stop losing weight. There is no reason to continue to go up in your dose if you are losing 2–4 pounds per month, as a higher dose may increase side effects,” she adds. 

Let your healthcare provider know if you have any concerns about your weight loss with Wegovy or if:

• You've been consistently following your treatment plan and lifestyle changes but aren’t losing weight

• You’re experiencing increased hunger or fatigue

• Side effects are impacting your quality of life

• You've started regaining weight

They may determine that you need more time to adjust to the medication or a different dosage, or they may recommend a different treatment, such as Zepbound or Saxenda. 

Building a support network can provide motivation and practical help while taking Wegovy. Think about joining weight loss support groups or Wegovy-specific online communities to connect with people who understand firsthand the experiences of taking this medication.

“I am always for finding support systems outside of your healthcare provider,” Reisdorf says. “However, it’s important to ensure that these groups share evidence-based information and encourage healthy, sustainable habits rather than extreme practices, so be cautious of what type of group you are joining.”

Remember that your journey with Wegovy is unique, and try to avoid comparing your results to others. Stay focused on your progress and be sure to celebrate non-scale victories you notice along the way, such as higher energy, better mood, and improved medical markers like blood pressure or cholesterol levels.

You may reach a point in your Wegovy treatment when weight loss stalls or slows down significantly despite lifestyle changes. 

If you’re wondering, “why am I not losing weight on Wegovy?” here are some potential causes:

• Your body is adapting to changes in diet and exercise. Weight loss injections like Wegovy can suppress appetite and reduce overall calorie intake. These changes in diet combined with an increase in physical activity may cause your metabolism to slow down to help conserve energy.

• You may need more time on the medication. Though Wegovy can lead to significant weight loss, how long it takes semaglutide to work will vary from person to person. Some people start to lose weight within a few weeks, while others may take up to three months or longer. 

• You may be ready to move up to the next dose strength. If you’re taking less than the maximum dose of Wegovy (2.4 mg) and aren’t losing weight, talk to your healthcare provider about potentially increasing your dose. 

• Other health conditions can impact weight loss. Some studies found that people with type 2 diabetes lost less weight on semaglutide compared to people without type 2 diabetes, though it’s not entirely clear why this happens. One explanation could be that some diabetes medications may cause weight gain. 

Your healthcare provider is your best partner on this journey. Reach out if you have any concerns or questions about your Wegovy treatment. 

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Wegovy can be an effective tool for weight management, but it’s not a miracle drug. Clinical research and real-world experience show that healthy lifestyle changes can help maximize your weight loss on Wegovy and support your long-term health goals.

• Certain lifestyle changes may help boost weight loss on Wegovy. They include regular exercise, a nutrient-dense diet, good sleep and stress management, and working closely with your HCP to monitor progress. 

• Consistency is the key—both with the medication schedule and healthy habits. Focus on sustainable changes that you can stick to for the long term.

• Talk to your healthcare provider if you’re not losing weight on Wegovy despite diet and exercise changes. They may recommend adjusting your dose, giving it more time, or trying a different medication altogether. 

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How we reviewed this article

Every article on Health Guide goes through rigorous fact-checking by our team of medical reviewers. Our reviewers are trained medical professionals who ensure each article contains the most up-to-date information, and that medical details have been correctly interpreted by the writer.

Editorial Guidelines | Medical Review Process

Current version

February 28, 2025

Written by

Brandi Hunter

Fact checked by

Ecler Ercole Jaqua, MD, MBA, DABOM

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About the medical reviewer

Ecler Ercole Jaqua, MD, MBA, DABOM

Ecler Ercole Jaqua, MD, MBA, DABOM, is the associate program director of the Loma Linda University Family Medicine Residency.