Bupropion—sold under the brand names Wellbutrin and Zyban among others—is a prescription medication FDA-approved for depression, seasonal affective disorder, and smoking cessation. It falls into a class of antidepressants known as norepinephrine dopamine reuptake inhibitors (NDRIs), and works by increasing chemical activity in the brain. Here’s more on what you need to know about bupropion, its primary uses, and what side effects to be aware of before taking the drug.