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If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
We all feel blue from time to time. But if you’re struggling with depression, you know the feelings of sadness and hopelessness can be overwhelming. Just getting through the day can be a challenge. Fortunately, it doesn’t have to be this way. Effective treatment options are available to get you feeling like yourself and back to the things you enjoy doing. Find out how one option—Pristiq—may be able to help.
What is Pristiq?
Pristiq (desvenlafaxine) is a prescription medication used to treat depression. Pristiq belongs to a group of antidepressants called serotonin-norepinephrine reuptake inhibitors, or SNRIs. SNRIs work by increasing levels of serotonin and norepinephrine—two chemical messengers that send signals from one part of the body to another (Pfizer, 2018). Researchers believe that low levels of serotonin and norepinephrine contribute to depression (Sahli, 2016).
Pristiq is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) (Pfizer, 2018). If your healthcare provider has prescribed Pristiq to treat your depression, keep in mind that you may not see an improvement in your symptoms right away. Some people begin to feel better within two weeks of starting Pristiq, but it may take six weeks or longer to see the full effects (Machado-Vieira, 2010).
Pristiq can also be used “off-label” to treat other conditions, meaning the FDA didn’t explicitly approve it for those uses. A healthcare provider can prescribe drugs for an unapproved use if they decide that it’s the proper treatment for their patient.
Healthcare providers sometimes prescribe Pristiq off-label to treat the hot flashes and night sweats associated with menopause—especially for women that can’t take estrogen (Naseeruddin, 2021).
Pristiq side effects
Pristiq is generally well-tolerated, but side effects can occur. The most common side effect reported in clinical trials was nausea. Nausea is often the worst during the first week of treatment but tends to go away after that (Liebowitz, 2008). If you experience nausea with Pristiq, taking your dose with food may help.
Other common side effects of Pristiq include (Liebowitz, 2008; Pfizer, 2018):
- Decreased appetite
- Dry mouth
- Excessive sweating
- Sexual dysfunction (ex. reduced sex drive, ejaculation problems)
- Trouble sleeping
Be sure to let your healthcare provider know if any of these side effects don’t go away or affect your ability to take your medication.
Less commonly, Pristiq may cause rare and sometimes serious side effects, such as (Pfizer, 2018):
- Allergic reactions: Seek medical attention if you experience a rash, hives, swelling, or difficulty breathing.
- Glaucoma: Let your healthcare provider know about any eye problems you have.
- Low sodium levels: This is a potential concern, especially if you are older or take diuretic medications (sometimes called “water pills”).
- Lung problems: Contact your healthcare provider right away if you develop trouble breathing, a cough, or chest discomfort.
Causes of depression: genetics, environment, and others
Pristiq is available in doses of 25 mg, 50 mg, and 100 mg extended-release tablets. The typical starting dose for depression is 50 mg daily. Your healthcare provider may gradually increase your dose depending on your symptoms and side effects up to a maximum dose of 100 mg daily. Because Pristiq is formulated as an extended-release tablet, it is important not to crush or chew your dose—doing so can affect how quickly the medication is released into your body and cause side effects (Pfizer, 2018).
Before starting Pristiq, be sure to review these warnings and discuss any concerns with your healthcare provider.
Suicidal thoughts and behaviors
The FDA has labeled all antidepressants, including Pristiq, with a boxed warning—their strongest warning—regarding the increased risk of suicidal thoughts and behaviors in children and young adults. People over the age of 24 did not show an increased risk, and individuals 65 and older had a decrease in these thoughts and behaviors. The FDA notes that untreated depression can also lead to suicidal thoughts and behaviors, so it’s up to each person and their healthcare provider to weigh the risks and benefits. Family members and caregivers should monitor for worsening symptoms or suicidal thoughts, especially during the first several months of treatment, and report any changes (Pfizer, 2018).
Rarely, Pristiq may cause serotonin syndrome—a serious and potentially life-threatening condition that occurs when serotonin levels in the brain become too high. Taking Pristiq with other medications that also affect serotonin (such as other antidepressants and certain pain drugs) increases your risk. The symptoms of serotonin syndrome can progress quickly, so be sure to seek medical attention right away if you experience any of the following (Foong, 2018; Pfizer, 2018):
- Agitation or restlessness
- Changes in blood pressure
- Fast heartbeat
- Muscle stiffness or muscle spasms
- Nausea or vomiting
- Trouble sleeping
- Trouble with balance or coordination
You may experience withdrawal-type symptoms if you stop taking Pristiq—especially if you stop abruptly. Withdrawal symptoms generally start a few days after stopping Pristiq and can last for several weeks (Fava, 2018). If you’re interested in stopping Pristiq, speak with your healthcare provider first. They’ll likely develop a plan to decrease your dose slowly over time.
Withdrawal symptoms may include (Pfizer, 2018):
- Abnormal dreams
- Changes in your mood
- Electric shock sensations (paresthesia)
- Irritability or agitation
- Problems sleeping
- Ringing in your ears (tinnitus)
Pristiq may increase your risk of bleeding, including nose bleeding, bruising, and bleeding in the stomach. Taking Pristiq with aspirin, NSAIDs (like ibuprofen or naproxen), or blood thinners increases this risk (Pfizer, 2018).
8 types of depression: symptoms and treatments
Pregnancy and breastfeeding
Let your healthcare provider know if you’re pregnant or plan to become pregnant before starting Pristiq. SNRIs like Pristiq are sometimes used during pregnancy, but risks do exist. Babies exposed to an SNRI during the third trimester of pregnancy may develop withdrawal-type reactions after delivery, including excessive crying, irritability, difficulty sleeping, and trouble feeding (Dubovicky, 2017). You and your healthcare provider will discuss the risks and benefits of starting or withholding treatment since untreated depression can also increase pregnancy complications.
If you’re interested in breastfeeding your baby, talk with your healthcare provider about the risks. While Pristiq is present in breastmilk, a small study did not show any side effects in the babies (Pfizer, 2018). If your healthcare provider recommends you continue Pristiq while breastfeeding, monitor your baby for excessive sleepiness and adequate weight gain (LactMed, 2021).
Some conditions may increase your risk of developing complications from Pristiq. Let your healthcare provider know if any of the following situations apply to you (Pfizer, 2018):
- Bleeding problems
- Heart problems
- High blood pressure
- High cholesterol
- History of bipolar disorder, mania, or hypomania, or a family member with these conditions
- History of seizures
- Kidney or liver problems
- Previous allergic reaction to desvenlafaxine (Pristiq) or venlafaxine (Effexor XR)
- Previous stroke
Pristiq may interact with certain medications. Always keep an updated list of all the medicines you take—including nonprescription, over-the-counter products—and share this information with your healthcare providers and pharmacist any time there are changes.
Some medications should never be taken with Pristiq since they can increase the risk of serotonin syndrome. Never take Pristiq with (Pfizer, 2018):
- MAOIs (monoamine oxidase inhibitors): Don’t start Pristiq within 14 days of stopping an MAOI and don’t start an MAOI within seven days of stopping Pristiq. MAOIs include selegiline, tranylcypromine, isocarboxazid, and phenelzine.
- Linezolid (Zyvox)
- Intravenous (IV) methylene blue
Other drugs may increase your risk of serotonin syndrome if taken with Pristiq. They include (Foong, 2018):
- Other SNRIs like duloxetine (Cymbalta; see Important Safety Information) and venlafaxine (Effexor XR; see Important Safety Information)
- SSRIs (selective serotonin reuptake inhibitors), such as paroxetine (Paxil; see Important Safety Information), fluoxetine (Prozac; see Important Safety Information), and sertraline (Zoloft; see Important Safety Information)
- TCAs (tricyclic antidepressants) like clomipramine (Anafranil) and imipramine
- Cough and cold products that contain dextromethorphan (“DM”) and chlorpheniramine
- Natural health supplements like St. John’s wort, L-tryptophan, and diet pills
- Drugs of abuse, such as ecstasy (MDMA), amphetamine, and cocaine
Certain medications can increase the chance of bleeding with Pristiq. Let your healthcare provider know if you take (Pfizer, 2018):
- NSAIDs like ibuprofen or naproxen
- Blood thinners like warfarin, apixaban (Eliquis), or rivaroxaban (Xarelto)
- Antiplatelet drugs like clopidogrel (Plavix) or ticagrelor (Brilinta)
This is not a complete list of all the medications that may interact with Pristiq. Always talk to your healthcare provider before starting anything new.
Depression doesn’t have to rule your life. Many of us find it difficult to admit when we need help, but taking care of your mental health is nothing to be ashamed of. Talk to your healthcare provider about all your symptoms and concerns. They may recommend Pristiq as one part of your treatment plan to get you back to feeling your best.
- Drugs and Lactation Database (LactMed). (2021). Desvenlafaxine. National Library of Medicine (US). Retrieved from https://pubmed.ncbi.nlm.nih.gov/30000652/
- Dubovicky, M., Belovicova, K., Csatlosova, K., & Bogi, E. (2017). Risks of using SSRI / SNRI antidepressants during pregnancy and lactation. Interdisciplinary toxicology, 10(1), 30–34. doi: 10.1515/intox-2017-0004. Retrieved from https://pubmed.ncbi.nlm.nih.gov/30123033/
- Fava, G. A., Benasi, G., Lucente, M., Offidani, E., Cosci, F., & Guidi, J. (2018). Withdrawal Symptoms after Serotonin-Noradrenaline Reuptake Inhibitor Discontinuation: Systematic Review. Psychotherapy and psychosomatics, 87(4), 195–203. doi: 10.1159/000491524. Retrieved from https://pubmed.ncbi.nlm.nih.gov/30016772/
- Foong, A. L., Patel, T., Kellar, J., & Grindrod, K. A. (2018). The scoop on serotonin syndrome. Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC, 151(4), 233–239. doi: 10.1177/1715163518779096. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141939/
- Liebowitz, M. R., Manley, A. L., Padmanabhan, S. K., Ganguly, R., Tummala, R., & Tourian, K. A. (2008). Efficacy, safety, and tolerability of desvenlafaxine 50 mg/day and 100 mg/day in outpatients with major depressive disorder. Current medical research and opinion, 24(7), 1877–1890. doi: 10.1185/03007990802161923. Retrieved from https://pubmed.ncbi.nlm.nih.gov/18507895/
- Machado-Vieira, R., Baumann, J., Wheeler-Castillo, C., Latov, D., Henter, I. D., Salvadore, G., & Zarate, C. A. (2010). The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments. Pharmaceuticals (Basel, Switzerland), 3(1), 19–41. doi: 10.3390/ph3010019. Retrieved from https://pubmed.ncbi.nlm.nih.gov/27713241/
- Naseeruddin, R., Rosani, A., & Marwaha, R. (2021). Desvenlafaxine. In StatPearls [Internet]. Retrieved on Oct. 12, 2021 from https://pubmed.ncbi.nlm.nih.gov/30521250/
- Pfizer. (2018). Pristiq (desvenlafaxine): highlights of prescribing information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021992s042lbl.pdf
- Sahli, Z. T., Banerjee, P., & Tarazi, F. I. (2016). The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder. Expert Opinion on Drug Discovery, 11(5), 515–523. doi: 10.1517/17460441.2016.1160051. Retrieved from https://pubmed.ncbi.nlm.nih.gov/26971593/
Dr. Steve Silvestro is a board-certified pediatrician and Senior Manager, Medical Content & Education at Ro.