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Last updated: Feb 11, 2022
5 min read

DHEA for men: benefits and side effects

Dehydroepiandrosterone (DHEA) is a steroid hormone that men naturally produce in the adrenal glands, brain, and testes through their 20s. DHEA is pivotal to a young man’s development and contributes to many male sexual characteristics that define puberty, such as oily skin, body odor, and pubic hair. DHEA levels naturally drop starting in a man’s 30s. The research is mixed on whether DHEA supplements can be helpful for erectile dysfunction, muscle mass, and obesity.

Disclaimer

If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

You probably know that testosterone is the main male hormone, but what about DHEA? You might have heard that taking a DHEA supplement can improve sexual function, along with a whole slew of other benefits. 

Read on to learn more about the benefits and side effects of DHEA for men. 

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What is DHEA? 

Dehydroepiandrosterone (DHEA) is a steroid hormone that men’s bodies produce in the adrenal glands, brain, and testes. From there, it circulates into the bloodstream as dehydroepiandrosterone sulfate (DHEA-S or DHEA-sulfate), where the body converts it into testosterone and other male sex hormones called androgens

DHEA is pivotal to a young man’s development and contributes to many male sexual characteristics that define puberty—oily skin, body odor, and pubic hair growth (Webb, 2006). 

Although DHEA is the most prevalent steroid hormone in the human body and is sometimes referred to as the “fountain of youth hormone,” a man’s supply won’t last forever (Webb, 2006). 

Levels of DHEA peak between ages 20 and 30, then the number starts to decline. By the time a man is 70–80 years old, his DHEA hormone levels are 10–20% of what they were when he was young (Neunzig, 2014). Once faced with low DHEA levels, some older men turn to DHEA supplements as replacement therapy (MedlinePlus, 2021). 

DHEA benefits for men

There are many claims out there about the potential health benefits of DHEA for men. Over the years, DHEA supplements have been touted for their ability to enhance sexual function, improve energy, treat adrenal insufficiency, and manage body fat and body composition. 

However, research on the benefits of DHEA has produced mixed results, and large, randomized trials are needed to confirm DHEA’s potential benefits for well-being (Rutkowski, 2014). Before starting DHEA, discuss the potential benefits with your healthcare provider. 

DHEA for erectile dysfunction

Since DHEA turns into sex hormones, it seems only natural that men would turn to the supplemental form to better their sex lives. Several small studies have suggested that DHEA can improve erectile dysfunction (ED), a condition where a man can’t get or maintain an erection sufficient for satisfying sex.

One study in Urology looked at men with ED and found that those who took DHEA daily for six months had an improved ability to achieve or maintain an erection; however, it did not affect their testosterone levels (Reiter, 1999). Other studies have not shown that DHEA helps ED, so more research is needed. 

DHEA for muscle mass and muscle strength

According to the NIH’s report on Dietary Supplements for Exercise and Athletic Performance, DHEA has not demonstrated any proven benefit for physical performance in terms of increases in muscle strength, aerobic capacity, lean body mass, or testosterone levels in men (NIH, 2021).

DHEA for obesity

Some small studies suggest that DHEA may help reduce abdominal fat and insulin resistance, factors linked to type 2 diabetes (Villareal, 2004). However, other studies do not show that DHEA is effective for weight loss and treating obesity (Jedrzejuk, 2003).

More research is required to identify an association between DHEA and obesity or weight loss.

DHEA for immune function

Little evidence exists to explain DHEA’s potential effect on the immune system and immune function. For the few immune diseases for which DHEA has been tested, like Sjogren syndrome, the results have not been promising (Hartkamp, 2008). There is not enough data to know whether DHEA can help with other immune conditions like ulcerative colitis, systemic lupus erythematosus, or Crohn’s disease (MedlinePlus, 2021). 

DHEA side effects in men

Additional research is needed to determine the safety of DHEA supplementation. According to the NIH, DHEA is probably safe to take at regular doses (50 mg per day) for less than two years; it is possibly unsafe if taken at higher doses or for more extended periods (MedlinePlus, 2021). 

Most side effects of DHEA supplements are mild and can include acne and an upset stomach. Some men may note breast pain or enlargement (MedlinePlus, 2021). 

DHEA Interactions and Risk Factors

DHEA supplements may be harmful to people with health conditions such as depression, bipolar disorder, diabetes, heart disease, liver disease, and prostate cancer. They also carry a list of potential interactions with various medications (MedlinePlus, 2021). 

Seek medical advice regarding any possible drug interactions with medicines you may be taking, like antidepressants, diabetes medications, blood thinners, testosterone supplements, and others (MedlinePlus, 2021). 

DHEA dosage

Although the DHEA dosage varies by the specific need and formula, the typical daily dose is approximately 50–100 mg by mouth (MedlinePlus, 2021). DHEA supplements are potentially unsafe if you use them for longer than two years or take more than 100 mg per day.

DHEA for women

In addition to men’s health, DHEA supplements are also utilized for various women’s wellness issues, such as vaginal atrophy. 

Vaginal atrophy is a condition that occurs when the vaginal walls become thinner after menopause—an event that marks the natural decline in a woman’s reproductive hormones around age 40 or 50. The vaginal dryness or inflammation of the vaginal walls can lead to pain during sexual intercourse and urinary symptoms. 

Prasterone (brand name Intrarosa) inserts were approved by the FDA in 2016 and can reduce pain during sex in postmenopausal women. The active ingredient in prasterone is DHEA (FDA, 2016). 

Another potential benefit of DHEA for women is its potential anti-aging properties. Some research suggests that taking DHEA might improve women’s skin appearance after menopause (MedlinePlus, 2021).

Women who are pregnant or may become pregnant or have breast cancer or ovarian cancer should not use DHEA supplementation. 

The bottom line

As you can see above, DHEA may provide some benefits for men, but the research is mixed, and we need more studies to really understand its benefits and risks. At the end of the day, if you’re considering supplementing with DHEA, it’s best to have a conversation with your healthcare provider so that they can help you make an informed (and safe) decision.

References

  1. Hartkamp, A., Geenen, R., Godaert, G. L., Bootsma, H., Kruize, A. A., Bijlsma, J. W., et al. (2008). Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. Annals of the Rheumatic Diseases, 67(1), 91–97. doi:10.1136/ard.2007.071563. Retrieved from https://pubmed.ncbi.nlm.nih.gov/17545193/
  2. Jedrzejuk, D., Medras, M., Milewicz, A., & Demissie, M. (2003). Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: effects on fat distribution, insulin sensitivity and lipid metabolism. The Aging Male : the official journal of the International Society for the Study of the Aging Male, 6(3), 151–156. Retrieved from https://pubmed.ncbi.nlm.nih.gov/14628495/
  3. MedlinePlus. (2021). DHEA. Retrieved on Feb. 3, 2022 from https://medlineplus.gov/druginfo/natural/331.html
  4. National Institutes of Health (NIH). (2021). Dietary supplements for exercise and athletic performance. Retrieved on Feb. 3, 2022 from https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/
  5. Neunzig, J. & Bernhardt, R. (2014) Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones. PLoS ONE 9(2): e89727. doi:10.1371/journal.pone.0089727. Retrieved from https://pubmed.ncbi.nlm.nih.gov/24586990/
  6. Reiter, W. J., Pycha, A., Schatzl, G., Pokorny, A., Gruber, D. M., Huber, J. C., et al. (1999). Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study. Urology, 53(3), 590–595. doi: 10.1016/S0090-4295(98)00571-8. Retrieved from https://pubmed.ncbi.nlm.nih.gov/10096389/
  7. Rutkowski, K., Sowa, P., Rutkowska-Talipska, J. et al. (2014). Dehydroepiandrosterone (DHEA): hypes and hopes. Drugs, 74, 1195–1207. doi: 10.1007/s40265-014-0259-8. Retrieved from https://pubmed.ncbi.nlm.nih.gov/25022952/
  8. U.S. Food and Drug Administration (FDA). (2016). FDA approves Intrarosa for postmenopausal women experiencing pain during sex. Retrieved on Feb. 3, 2022 from https://www.fda.gov/news-events/press-announcements/fda-approves-intrarosa-postmenopausal-women-experiencing-pain-during-sex
  9. Villareal, D. T. & Holloszy, J. O. (2004). Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA, 292(18), 2243–2248. doi:10.1001/jama.292.18.2243. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15536111/
  10. Webb, S. J., Geoghegan, T. E., Prough, R. A., & Michael Miller, K. K. (2006). The biological actions of dehydroepiandrosterone involve multiple receptors. Drug Metabolism Reviews, 38(1-2): 89-116. doi: 10.1080/03602530600569877. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423429/