Selenium benefits: here are 7 that are proven by science

Mike Bohl, MD, MPH, ALM - Contributor Avatar

Written by Linnea Zielinski 

Mike Bohl, MD, MPH, ALM - Contributor Avatar

Written by Linnea Zielinski 

last updated: Dec 19, 2019

6 min read

What does your body need to keep your metabolism and thyroid function up to snuff? Getting enough fuel and having some muscle mass may help your metabolism, but you’re not going to keep your thyroid healthy by living off of protein powder for the gains. Although our metabolisms are quite complicated, there is one thing we know is absolutely critical for keeping the calorie-burning furnace stoked: selenium. This essential mineral is a trace element we can get through dietary sources and supplements. But your metabolism isn’t all it powers.

Selenium is also involved in processes throughout your body, starting at your brain and extending to the cells at the tips of your toes. Many of its health benefits are brought about by proteins containing selenium, called selenoproteins (Labunskyy, 2014). But, like with many nutrients we need, getting too much can be just as dangerous as too little. Knowing your needs helps you strike the perfect balance between low levels of selenium and selenium toxicity, a serious condition that can cause side effects such as hair loss, fatigue, nausea, and vomiting. The recommended daily allowance (RDA) for adults over the age of 14 need 55 micrograms (mcg) daily, though this number jumps to 60 mcg for pregnant women and 70 mcg for breastfeeding women (NIH, 2019).

But you should always talk to a health professional who can assess your individual needs. Some people, like those with gastrointestinal conditions such as Crohn’s disease, HIV, or kidney problems requiring dialysis, have issues absorbing selenium and may, therefore, need to take higher doses. Always follow medical advice with selenium supplements to avoid risking toxicity.

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Health benefits of selenium

We cannot produce selenium ourselves, and that means we have to rely on our diet, selenium supplements, or a combination of the two to get enough. Although there’s nothing wrong with taking a high-quality supplement, it shouldn’t be difficult for people already trying to eat a healthy diet low in processed foods to keep their selenium levels up through dietary sources alone. It might take a little planning, but we think once you read these health benefits of selenium, you’ll agree it’s well worth the effort.

May protect against heart disease

A meta-analysis of 25 studies found that increasing selenium concentrations (taken from the blood and toenails) by 50% decreased the risk of heart disease by 24% (Flores-Mateo, 2006). Researchers believe that a lot of this has to do with the anti-inflammatory effects of this mineral. Inflammation is a risk factor for coronary heart disease. And another meta-analysis of 16 clinical trials found that selenium supplementation successfully decreased serum C-reactive protein (CRP), an inflammation marker. The same review found that at the same time, this essential mineral also raised levels of a powerful antioxidant called glutathione peroxidase (Ju, 2017). 

So selenium may not only lower inflammation markers but may also ease oxidative stress, a condition in which free radicals and antioxidants are unbalanced in the body leading to cellular damage. Oxidative damage is also associated with several chronic diseases, including cardiovascular disease (CVD).

Boosts immune system

But selenium’s ability to lower oxidative damage does more than just boost your heart health. Decreasing oxidative stress actually lowers inflammation and strengthens your immune system. We actually have types of immune responses: Th1 type, to viruses and intracellular bacteria, and Th2 type, to parasitic worms and extracellular parasites. Selenium may boost the Th1-type immune response more than Th2 type. But studies do underscore that the essential mineral selenium is able to enhance the immune response and that selenium deficiency may slow immune cell response (Hoffmann, 2008). Selenium supplementation also increases white blood cell count and may also enhance the function of T-cells, a specific type of white blood cell (Hawkes, 2001).

Prevents damage from free radicals

We already mentioned the antioxidant properties of selenium. Acting as an antioxidant, this trace mineral can balance out free radicals in the body and prevent them from causing the cellular damage associated with oxidative stress. It’s worth noting that free radicals are natural byproducts of some essential processes in your body, like metabolism. But external sources can also produce free radicals, such as pollution and cigarette smoke.

May support cognitive function

Alzheimer’s isn’t the only neurological condition with which oxidative stress is associated, though. It has also been linked to Parkinson’s and multiple sclerosis. So selenium may lessen oxidative damage and, in that way, decrease your risk of Alzheimer’s and protect your cognitive health. And patients with Alzheimer’s have been found to have low levels of selenium, as well as other nutrients such as vitamin C and vitamin E (de Wilde, 2017).

Though antioxidants seem to be able with the retention of cognitive skills, this benefit of selenium isn’t only tied to people with Alzheimer’s. One study found that adults given a mixture of antioxidants that included selenium had better scores at the end of the research in episodic memory, executive functioning, and verbal memory—though improvement in the last skill was only seen if the participant was a nonsmoker or had low baseline levels of vitamin C (Kesse-Guyot, 2011). But even in cases involving neurological conditions, selenium may help. Another study gave participants who already had mild cognitive impairment one Brazil nut a day (the most potent dietary source of this mineral) for six months to boost their blood selenium. Compared to the control group, those given Brazil nuts scores better at the end of the trial in verbal fluency and constructional praxis, the concept of fitting together different pieces to form a uniform whole that humans use across many different activities (Cardoso, 2016).

Important for thyroid health

Finally, we get to the thyroid gland and, by extension, your metabolism. This small but powerful part of your body has the highest concentration of selenium of all of your tissue (Ventura, 2017). And the thyroid does more than regulate your metabolism through the release of thyroid hormone. This butterfly-shaped gland at the front of your neck also helps with proper growth. But low selenium has been connected with thyroid disease, an epidemiological study found (Wu, 2015). And not just hypothyroidism, an underactive thyroid, but also Hashimoto’s thyroiditis, an autoimmune condition in which the body attacks the thyroid gland.

But increased selenium intake may benefit people with either form of thyroid disease. Three months of selenium supplementation successfully lowered antibodies in participants with Hashimoto’s in one study (Toulis, 2010). Another found that the two highest consumption rates of dietary selenium were associated with a lower risk of developing subclinical hypothyroidism, a condition in which the thyroid is underactive but not to a degree at which healthcare providers prescribe thyroid hormone replacement (Andrade, 2018). But while selenium may help those with thyroid disease, supplementation should be an addition, not a substitute for medical treatment.

May support prostate health

It’s important for us to cover one thing immediately: Although it’s been reported that selenium can lower your cancer risk, a meta-analysis found that research actually isn’t indicative of that (Vinceti, 2018). That’s not to say that the current research on this mineral and cancer prevention isn’t hopeful. Selenium has proven capable of lowering DNA damage and oxidative stress, both of which are linked to cancer risk (Rayman, 2005). Perhaps the most hopeful is a study published in 2016. The researchers found that higher blood selenium levels were associated with lower rates of several types of cancer, including lung cancer, breast cancer, and prostate cancer. Unfortunately, even this study did not find an association between selenium and skin cancer, bladder cancer, or colorectal cancer risk (Cai, 2016).

May fight asthma symptoms

Allergic asthma, the most common type of this condition, is at its core a chronic inflammatory disorder (Murdoch, 2010). The anti-inflammatory effects of selenium mean this mineral may help lessen the symptoms of asthma. Although more work needs to be done on human health, animal research has shown that selenium supplementation may make sense as a part of asthma treatment—depending on the individual’s baseline selenium status. Supplementing with this mineral seems more effective in conditions where blood selenium was low (Norton, 2011). 

But that likely won’t rule many people out for the benefits of selenium supplementation. Asthmatics have been found to have low selenium levels. But even among people with mild to moderate asthma with low selenium compared to those without the inflammatory condition, a relationship between lung function and selenium status can be seen. Higher selenium levels are associated with better lung function even before treatment with supplements (Guo, 2011).

How to get enough selenium

For most people, getting enough selenium is as easy as checking that a couple of foods with solid selenium content are in their daily or weekly diet. But raising low selenium levels doesn’t even require you to eat food sources of this mineral daily—though you likely are already. Common foods like meat, seafood, and dairy products are all quality sources, but even vegans can easily get a quality amount of selenium just by eating a Brazil nut a couple of times a week.

But dietary supplements may be necessary or helpful for some people in order to improve or maintain selenium status. Supplements may contain different forms of selenium, such as sodium selenite, selenomethionine, or even both. Although short-term high doses may be necessary to correct selenium deficiency, these should always be supervised by a medical professional as selenium toxicity can be dangerous.


If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

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How we reviewed this article

Every article on Health Guide goes through rigorous fact-checking by our team of medical reviewers. Our reviewers are trained medical professionals who ensure each article contains the most up-to-date information, and that medical details have been correctly interpreted by the writer.

Current version

December 19, 2019

Written by

Linnea Zielinski

Fact checked by

Mike Bohl, MD, MPH, ALM

About the medical reviewer

Dr. Mike is a licensed physician and a former Director, Medical Content & Education at Ro.