How long do Mounjaro side effects last?

last updated: Sep 18, 2023

1 min read

Mounjaro (tirzepatide) is FDA-approved to treat type 2 diabetes when paired with healthy lifestyle changes. It can also lead to substantial weight loss. We asked Dr. Felix Gussone, MD about how long Mounjaro's side effects last.

Mounjaro Important Safety Information: Read more about serious warnings and safety info.

Weight loss

Fad diets stop here

If appropriate, get effective weight loss treatment prescribed for your body.

Fad diets stop here
Fad diets stop here

How long do Mounjaro side effects last?

Mounjaro (tirzepatide) is a type 2 diabetes medication you inject once a week, and it may also be prescribed off-label to help with weight loss. Mounjaro is similar to drugs like Ozempic (semaglutide) and Wegovy in both how it works and possible side effects. 

How long side effects from Mounjaro last can vary from person to person, but generally, side effects are temporary and occur when starting the medication and with increases in the doses.  Mounjaro is a long-acting drug, meaning that these side effects could last days to weeks, depending on the individual.  

Mounjaro’s side effects are gastrointestinal and include nausea, diarrhea, reduced appetite, vomiting, constipation, indigestion, and stomach pain. Serious side effects are rare but may include pancreatitis (inflammation of the pancreas), kidney or gallbladder problems, or an allergic reaction to Mounjaro, which requires immediate medical attention. 

If you are experiencing side effects, speak with your healthcare provider about the option to adjust your dosage to reduce the severity of those side effects as your body acclimates to the medication.


If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

How we reviewed this article

Every article on Health Guide goes through rigorous fact-checking by our team of medical reviewers. Our reviewers are trained medical professionals who ensure each article contains the most up-to-date information, and that medical details have been correctly interpreted by the writer.

Current version

September 18, 2023

Written by

Felix Gussone, MD

Fact checked by

Yael Cooperman, MD

About the medical reviewer

Yael Cooperman is a physician and works as a Senior Manager, Medical Content & Education at Ro.

Stay in touch on your weight loss journey

Sign up for news, updates, promotions and more.

By sharing your email, you acknowledge that your email will be used consistent with our privacy policy and terms of use including for marketing purposes.

    get video check ups with qualified medical advisors to review your progress on the Body Program

    $99 to get started, $145/mo for ongoing care

    What's included?

    Provider consultation

    GLP-1 prescription (if appropriate)

    Insurance concierge

    Ongoing care & support

    Tools to track progress

    Start now – $99

    Please note: The cost of medication and lab testing is not included in the Body Program

    Learn more about pricing

    Medication is prescribed only if appropriate.