Ozempic and Wegovy before and after: real weight loss stories

In recent years, two medications, Ozempic and Wegovy, have revolutionized the approach to weight loss and management. Originally developed for diabetes treatment, Ozempic (semaglutide) and its higher-dose counterpart Wegovy have shown remarkable efficacy in weight reduction, offering new hope for those struggling with weight issues.

Ozempic and Wegovy, both based on the active ingredient semaglutide, were primarily designed to improve blood sugar control in type 2 diabetes. Ozempic is widely known for its off-label use in weight loss, while Wegovy is specifically dosed and approved for chronic weight management. These medications belong to the GLP-1 receptor agonist class and require weekly self-administered injections just under the skin.

Ozempic and Wegovy function by mimicking GLP-1, a hormone that regulates appetite and food intake. This action not only assists in controlling blood sugar levels but also significantly reduces hunger and slows the transit of food through the digestive system. This leaves you feeling fuller for longer and reduces appetite significantly, leading to decreased calorie consumption and weight loss.

The life-changing effects of Ozempic and Wegovy are best illustrated through personal narratives. Josh, a veteran, describes his transformation: “You walk up a flight of stairs and you can’t breathe... I got to catch my breath from tying my shoe... Trying to battle through those things and hopefully getting back to a point where I don’t need medication for high blood pressure anymore.” His journey from a fit military lifestyle to struggling with everyday tasks highlights the profound changes these medications can bring.

^{*Paid testimonials from Ro Body Program members taking branded GLP-1 medications.}

Marva's story emphasizes the emotional side of weight loss. She recounts, “My journey is just about feeling like myself, one step at a time... I used to be a plus-size model...but shunned the camera for the past year and a half. To feel confident in front of the camera again...just means the world to me.”

^{*Paid testimonials from Ro Body Program members taking branded GLP-1 medications.}

Kerry shares her ongoing progress, “I have a picture in my mind of the person I really want to be... I’m picking up new little skills and habits... Like belly dancing videos, which really tone up my middle section. And I love my yoga practice; maybe someday I will be a yoga instructor... I’m really excited about the future.”

^{*Paid testimonials from Ro Body Program members taking branded GLP-1 medications.}

These stories showcase not only significant weight loss but also improvements in self-esteem, lifestyle, and overall health.

Healthcare professionals recognize the potential of both Ozempic and Wegovy in managing weight. Clinical studies support their use, indicating substantial weight loss in comparison to placebos. These medications are used as part of a comprehensive weight management plan, including diet and exercise. Patients can expect to lose an average of 15-20% of their body weight in 1 year (compared to 2.4-3.1% with diet and exercise alone). These results are based on studies of branded medications in people without diabetes with BMI ≥30, or BMI ≥27 plus a weight-related condition when paired with diet and exercise changes. 

Common side effects include gastrointestinal issues like nausea and diarrhea. More serious adverse effects can occur, so it's crucial for individuals, especially those with specific health conditions, to consult healthcare providers before starting these medications.

For best results, combining these medications with lifestyle changes is essential. A balanced diet and regular physical activity can significantly enhance their effectiveness, leading to more sustainable health outcomes.

Ozempic and Wegovy are significant advancements in the field of weight management, offering new avenues for those seeking help with weight loss. Their ability to effect substantial changes in body weight, coupled with lifestyle modifications, can lead to improved health and well-being. As with any medication, it's important to approach their use under medical guidance to ensure safety and effectiveness.

If you’re considering treatment with GLP-1 medications like Ozempic or Wegovy, speak to a licensed healthcare professional through the Ro Body program, which can help you get on track for your weight loss journey.

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Current version

January 10, 2024

Written by

Health Guide Team

Fact checked by

Yael Cooperman, MD

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About the medical reviewer

Yael Cooperman, MD, Ro

Yael Cooperman is a physician and works as a Senior Manager, Medical Content & Education at Ro.