Do Wegovy injections hurt?

Giving yourself an injection seems daunting, but we spoke to Dr. Felix Gussone, MD about whether these injections hurt or not. 

For most people, injecting Wegovy isn’t painful because the injection pen uses a tiny needle that goes just under the skin. These so-called subcutaneous injections typically don’t hurt at all, and they are significantly less painful than injections into muscles, like when you get a flu shot. One study showed that people injecting semaglutide (the active ingredient in Wegovy), which is administered for diabetes or weight loss in the skin of the abdomen, thigh, or upper arm, produced little to no injection‐site pain. 

Make sure you follow the manufacturer’s instructions when using the Wegvy injection pen and choose a different injection site each time you inject Wegovy. If you use the same spot for every dose, skin irritation or other skin reactions may occur, which can make the next injection more painful.

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Every article on Health Guide goes through rigorous fact-checking by our team of medical reviewers. Our reviewers are trained medical professionals who ensure each article contains the most up-to-date information, and that medical details have been correctly interpreted by the writer.

Current version

August 31, 2023

Written by

Felix Gussone, MD

Fact checked by

Yael Cooperman, MD

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About the medical reviewer

Yael Cooperman, MD, Ro

Yael Cooperman is a physician and works as a Senior Manager, Medical Content & Education at Ro.